5-Aminovaleric acid hydrochloride

Base Information

• Chemical Name: 5-Aminovaleric acid hydrochloride
• CAS No.: 627-95-2
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.609
• Hs Code.: 2922499990
• European Community (EC) Number: 211-021-1
• DSSTox Substance ID: DTXSID80211773
• ChEMBL ID: CHEMBL1256511
• Mol file: 627-95-2.mol

Synonyms:5-aminopentanoic acid;5-aminovaleric acid;5-aminovaleric acid hydrochloride;delta-aminovaleric acid

Chemical Property of 5-Aminovaleric acid hydrochloride

Chemical Property:

• Appearance/Colour: light pink crystalline powder
• Vapor Pressure: 0.00825mmHg at 25°C
• Melting Point: 95-97 °C(lit. )
• Boiling Point: 247.5 °C at 760 mmHg
• Flash Point: 103.5 °C
• PSA: 63.32000
• Density: 1.0962 g/cm3
• LogP: 1.70230
• Sensitive.: Hygroscopic
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 72.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Aminovaleric acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CCN)CC(=O)O.Cl
• Uses: 5-Aminovaleric Acid Hydrochloride is used in the synthesis of precursors and fragments of antibiotics XIV and in the study of the reaction of thiolactams with ethyl chloroacatate. Reagent in the preparation of hydroxymethyl dihydroisoxazole derivatives useful as antibiotics agents.

Technology Process of 5-Aminovaleric acid hydrochloride

There total 7 articles about 5-Aminovaleric acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Methyl N-(trichloroacetyl)-5-aminopentanoate (138286-84-7) → 5-amino-valeric acid ; hydrochloride (627-95-2)

Guidance literature:

With potassium hydroxide; In methanol; Ambient temperature;

DOI:10.1021/jo00031a052

Reference yield: 98.0%

piperidin-2-one (675-20-7) → 5-amino-valeric acid ; hydrochloride (627-95-2)

Guidance literature:

With hydrogenchloride; water; at 90 ℃; for 24h;

DOI:10.1002/ejoc.201801134

Reference yield: 96.0%

5-(Methoxycarbonylamino)valeriansaeure-methylester (70320-18-2) → 5-amino-valeric acid ; hydrochloride (627-95-2)

Guidance literature:

With hydrogenchloride; formic acid; In water; at 125 ℃; for 24h;

upstream raw materials:

piperidin-2-one

5-(Methoxycarbonylamino)valeriansaeure-methylester

Methyl N-(trichloroacetyl)-5-aminopentanoate

5-bromovaleric acid methyl ester

Downstream raw materials:

5-[2-hydroxy-2-(4-hydroxyphenyl)acetylamino]pentanoic acid benzyl ester

5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-fluoro-acetylamino}pentanoic acid

5-[3-hydroxy-3-(4-hydroxyphenyl)propionylamino]pentanoic acid benzyl ester

5-{2-[4-(ethyl-methoxy-phosphinoyloxy)phenyl]-2-hydroxy-acetylamino}pentanoic acid benzyl ester

Refernces

• 1、 Tommasi, Sara,Zanato, Chiara,Carabeo, Rey,Mangoni, Arduino A.,Dall'Angelo, Sergio,Zanda, Matteo. "An Efficient Route to N-Monosubstituted Guanidino-Lactams". . p. 3067 - 3078. Retrieved 2015/09/28.
• 2、 Groeger, Christian,Wenzel, Herbert R.,Tschesche, Harald. "Die Bedeutung der Rigiditaet des Peptidrueckgrats fuer die Inhibitoreigenschaften des BPTI - gezeigt mit semisynthetischen Strukturvarianten". . p. 948 - 950. Retrieved 2007/10/02.