2-BROMOMANDELIC ACID

Base Information

• Chemical Name: 2-BROMOMANDELIC ACID
• CAS No.: 7157-15-5
• Molecular Formula: C8H7 Br O3
• Molecular Weight: 231.046
• Hs Code.: 2918199090
• Mol file: 7157-15-5.mol

Synonyms:Mandelicacid, o-bromo- (7CI,8CI); (?à)-o-Bromomandelic acid

Chemical Property of 2-BROMOMANDELIC ACID

Chemical Property:

• Vapor Pressure: 1.39E-06mmHg at 25°C
• Boiling Point: 384°C at 760 mmHg
• Flash Point: 186°C
• PSA: 57.53000
• Density: 1.759g/cm³
• LogP: 1.56710
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromomandelic acid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMOMANDELIC ACID

There total 7 articles about 2-BROMOMANDELIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-bromophenyl methyl ketone (2142-69-0) → 2-bromomandelic acid (7157-15-5)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; at 90 ℃; for 24h;

DOI:10.3184/174751912X13551435784584

Reference yield: 70.0%

2-(2-bromophenyl)-2-hydroxyacetonitrile (52923-21-4,1269472-47-0,548478-30-4) → 2-bromomandelic acid (7157-15-5)

Guidance literature:

With hydrogenchloride; at 20 - 70 ℃; for 42h;

DOI:10.1021/ja0259842

Reference yield: 66.0%

α-bromoacetophenone (70-11-1) → 2-bromomandelic acid (7157-15-5)

Guidance literature:

α-bromoacetophenone; With selenium(IV) oxide; ytterbium(III) triflate; In 1,4-dioxane; water; at 90 ℃; for 18h;

With sodium hydroxide; In water;

With hydrogenchloride; In water; pH=1;

upstream raw materials:

Bromoform

ortho-bromobenzaldehyde

2-bromophenyl methyl ketone

2-(2-bromophenyl)-2-hydroxyacetonitrile

Downstream raw materials:

methyl 2-(2-bromophenyl)-2-hydroxyacetate

2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetic acid

methyl 2-(2-bromophenyl)-2-(tert-butoxy)acetate

methyl 2-(tert-butoxy)-2-[2-(3,4-dihydro-2H-1-benzopyran-6-yl)phenyl]acetate

Refernces

• 1、 -. "Nitrilases, nucleic acids encoding them and methods for making and using them". Page/Page column 70. . Retrieved 2016/01/09.
• 2、 Coles,Ellis,Leung,Sarson,Threlfall,Tizzard. "Relationships between the racemic structures of substituted mandelic acids containing 8- and 10-membered hydrogen bonded dimer rings". . p. 10816 - 10823. Retrieved 2015/02/19.