Technology Process of Butanedioic acid, 2-bromo-3-ethyl-, 4-methyl ester, [S-(R*,S*)]- (9CI)
There total 3 articles about Butanedioic acid, 2-bromo-3-ethyl-, 4-methyl ester, [S-(R*,S*)]- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen bromide; potassium bromide; sodium nitrite;
at -9 - -7 ℃;
for 2h;
Yield given;
DOI:10.1021/jo00057a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) potassium bis(trimethylsilyl)amide / 1.) THF, toluene, -74 deg C, 45 min, 2a.) -74 deg C, 10 min, 2b.) -74 deg C to RT
3: NaNO2, KBr, 2.5 N aq. HBr / 2 h / -9 - -7 °C
With
hydrogen bromide; potassium hexamethylsilazane; potassium bromide; sodium nitrite;
DOI:10.1021/jo00057a031
- Guidance literature:
-
Multi-step reaction with 2 steps
2: NaNO2, KBr, 2.5 N aq. HBr / 2 h / -9 - -7 °C
With
hydrogen bromide; potassium bromide; sodium nitrite;
DOI:10.1021/jo00057a031