N-benzyl-2,2-difluoroethanamine

Base Information

• Chemical Name: N-benzyl-2,2-difluoroethanamine
• CAS No.: 1184224-96-1
• Molecular Formula: C₉H₁₁F₂N
• Molecular Weight: 171.19
• Mol file: 1184224-96-1.mol

Synonyms:N-benzyl-2,2-difluoroethanamine

Chemical Property of N-benzyl-2,2-difluoroethanamine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2,2-difluoroethanamine

There total 1 articles about N-benzyl-2,2-difluoroethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

1-chloro-2,2-difluoroethane (338-65-8) + benzylamine (100-46-9) → N-benzyl-2,2-difluoroethanamine (1184224-96-1)

Guidance literature:

at 120 ℃; for 16h; Product distribution / selectivity; Autoclave;

Reference yield: 84.0%

N-benzyl-2,2-difluoroethanamine (1184224-96-1) → 2,2-difluorethylamine (430-67-1)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In toluene; at 80 ℃; for 10h; under 4500.45 Torr; Inert atmosphere;

Reference yield:

N-benzyl-2,2-difluoroethanamine (1184224-96-1) → N-ethylbenzylamine (14321-27-8)

Guidance literature:

With lithium aluminium tetrahydride; zinc(II) chloride; In diethyl ether; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.04.114

upstream raw materials:

1-chloro-2,2-difluoroethane

benzylamine

Downstream raw materials:

N-ethylbenzylamine

2,2-difluorethylamine

Refernces