6-Monodeoxy-6-monoamino-beta-cyclodextrine

Base Information

• Chemical Name: 6-Monodeoxy-6-monoamino-beta-cyclodextrine
• CAS No.: 29390-67-8
• Molecular Formula: C42H71 N O34
• Molecular Weight: 1134.01
• Hs Code.: 9999999999
• Mol file: 29390-67-8.mol

Synonyms:2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane,b-cyclodextrin deriv.;6-Amino-6-deoxy-b-cyclodextrin;6-Amino-6-deoxycyclomaltoheptaose; 6-Deoxy-6-amino-b-cyclodextrin; 6-Monoamino-b-cyclodextrin; 6-Monodeoxy-6-monoamino-b-cyclodextrin; 6A-Amino-6A-deoxy-b-cyclodextrin;Mono(6-amino-6-deoxy)-b-cyclodextrin; Mono(6-deoxy-6-amino)-b-cyclodextrin

Chemical Property of 6-Monodeoxy-6-monoamino-beta-cyclodextrine

Chemical Property:

• Melting Point: 203 °C (decomp)
• Boiling Point: 1527.8±60.0 °C(Predicted)
• PKA: 12.57±0.70(Predicted)
• PSA: 559.84000
• Density: 1.608±0.06 g/cm3(Predicted)
• LogP: -14.56390
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Soluble in water, DMF, DMSO.Insoluble in acetone, methanol, chlo

Purity/Quality:

98%min ^*data from raw suppliers

6-Monoamino-β-cyclodextrin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suitable for coupling to carboxyl- or aldehyde-containing ligands 6-Monoamino-β-cyclodextrin is synthesized as fluorescent sensor of moleclular recognition.

Technology Process of 6-Monodeoxy-6-monoamino-beta-cyclodextrine

There total 12 articles about 6-Monodeoxy-6-monoamino-beta-cyclodextrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

mono(6-azido-6-deoxy)β-cyclodextrin (98169-85-8) → 6(I)-amino-6(I)-deoxycyclomaltoheptaose (29390-67-8)

Guidance literature:

With triphenylphosphine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/0957-4166(90)90035-9

Reference yield: 90.0%

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin (67217-55-4) → 6(I)-amino-6(I)-deoxycyclomaltoheptaose (29390-67-8)

Guidance literature:

With ammonia; In water; at 20 ℃; for 168h;

DOI:10.1016/j.tetlet.2009.11.118

Reference yield: 88.0%

6-monodeoxy-6-monoamino-β-cyclodextrin hydrochloride → 6(I)-amino-6(I)-deoxycyclomaltoheptaose (29390-67-8)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃;

DOI:10.1039/d1nj00039j

upstream raw materials:

mono-6-deoxy-6-(p-tolylsulphonyl)-β-cyclodextrin

mono(6-azido-6-deoxy)β-cyclodextrin

6-deoxy-6-(N-hydroxylamino)-β-cyclodextrin

β‐cyclodextrin

Downstream raw materials:

mono-6-deoxy-6-[4-(benzyloxycarbonyl)-4-(tert-butyloxycarbonylamino)butyrylamino]-β-cyclodextrin

Refernces

• 1、 Cotner, Edward S.,Smith, Paul J.. "Phosphotyrosine binding by ammonium- and guanidinium-modified cyclodextrins". . p. 1737 - 1739. Retrieved 1998.
• 2、 Jiang, Rui-Jian,Zhao, Yu-Lin,Chen, Yun-Jian,Xiao, Dan,Wang, Fen,Han, Bin,Yang, Jian,Liao, Xia-Li,Yang, Li-Juan,Gao, Chuan-Zhu,Yang, Bo. "Synthesis, characterization, and in vitro evaluation of artesunate-β-cyclodextrin conjugates as novel anti-cancer prodrugs". . p. 19 - 25. Retrieved 2014.
• 3、 Jain, Mehak,Ravoo, Bart Jan. "Fuel-Driven and Enzyme-Regulated Redox-Responsive Supramolecular Hydrogels". . p. 21062 - 21068. Retrieved 2021.
• 4、 Park, Joon Woo,Song, Hee Eun,Lee, Soo Yeon. "Homodimerization and heteroassociation of 6-O-(2-sulfonato-6-naphthyl)-γ-cyclodextrin and 6-deoxy-(pyrene-1-carboxamido)-β-cyclodextrin". . p. 7071 - 7076. Retrieved 2003.
• 5、 Ghaeidamini, Marziyeh,Kharat, Ali N.,Haertlé, Thomas,Ahmad, Faizan,Saboury, Ali A.. "β-Cyclodextrin-Modified Magnetic Nanoparticles Immobilized on Sepharose Surface Provide an Effective Matrix for Protein Refolding". . p. 9907 - 9919. Retrieved 2018.
• 6、 Delattre, Fran?ois,Woisel, Patrice,Surpateanu, Gheorghe,Bria, Marc,Cazier, Francine,Decock, Patrick. "1,3-Dipolar cycloaddition reaction of bipyridinium ylides with the propynamido-β-cyclodextrin. A regiospecific synthesis of a new class of fluorescent β-cyclodextrins". . p. 1557 - 1562. Retrieved 2004.
• 7、 Machut, Cecile,Patrigeon, Julien,Tilloy, Sebastien,Bricout, Herve,Hapiot, Frederic,Monflier, Eric. "Self-assembled supramolecular bidentate ligands for aqueous organometallic catalysis". . p. 3040 - 3042. Retrieved 2007.
• 8、 Wei, Xueqin,Wu, Wanhua,Matsushita, Ryohei,Yan, Zhiqiang,Zhou, Dayang,Chruma, Jason J.,Nishijima, Masaki,Fukuhara, Gaku,Mori, Tadashi,Inoue, Yoshihisa,Yang, Cheng. "Supramolecular Photochirogenesis Driven by Higher-Order Complexation: Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate to Slipped Cyclodimers via a 2:2 Complex with β-Cyclodextrin". . p. 3959 - 3974. Retrieved 2018.
• 9、 Jiao, Pingxuan,Wang, Shouxin,Liang, Shuobin,Li, Man,Gao, Qianqian,Ji, Dezhong,Chen, Yingying,Li, Haiwei,Ran, Fuxiang,Zhang, Yongmin,Zhang, Lihe,Zhou, Demin,Xiao, Sulong. "Facile preparation and characterization of novel oleanane-type triterpene functionalized β-cyclodextrin conjugates". . p. 690 - 693. Retrieved 2019.
• 10、 White, Rachel J.,Plieger, Paul G.,Harding, David R.K.. "Synthesis of bifunctional peptide derivatives based on a β-cyclodextrin core with drug delivery potential". . p. 800 - 803. Retrieved 2010.