Technology Process of N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide
There total 11 articles about N-[(4aR,7aR)-7a-(5-fluorothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid;
In
chloroform;
at 20 ℃;
for 1.25h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: toluene / 22.5 h / Inert atmosphere; Reflux
2: tetrahydrofuran / 19 h / 20 °C / Inert atmosphere
3: zinc; acetic acid / 0.67 h / 20 °C
4: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
5: chiral HPLC (Column: Chiralcel OD / methanol; chloroform / Resolution of racemate
6: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) / chloroform / 1.25 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; acetic acid; zinc;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: zinc; acetic acid / 0.67 h / 20 °C
2: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
3: chiral HPLC (Column: Chiralcel OD / methanol; chloroform / Resolution of racemate
4: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium(0) / chloroform / 1.25 h / 20 °C / Inert atmosphere
With
tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; acetic acid; zinc;
In
methanol; dichloromethane; chloroform;