Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI)

Base Information

• Chemical Name: Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI)
• CAS No.: 518990-20-0
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Mol file: 518990-20-0.mol

Synonyms:Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI);Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro-

Chemical Property of Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI)

Chemical Property:

• Boiling Point: 493.8±45.0 °C(Predicted)
• PKA: 3.78±0.20(Predicted)
• Density: 1.509±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI)

There total 3 articles about Pyrano[4,3-c]pyrazole-3-carboxylic acid, 1,4,6,7-tetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylic acid ethyl ester (518990-21-1) → 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylic acid (518990-20-0)

Guidance literature:

With water; lithium hydroxide; In ethanol; at 10 - 50 ℃;

Reference yield:

Tetrahydro-4H-pyran-4-one (29943-42-8,143562-54-3) → 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylic acid (518990-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -80 - -70 °C / Inert atmosphere; Large scale

2: acetic acid; hydrazine hydrate / 20 - 30 °C

3: water; lithium hydroxide / ethanol / 10 - 50 °C

With water; hydrazine hydrate; acetic acid; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;

Reference yield:

→ 1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylic acid (518990-20-0)

Guidance literature:

upstream raw materials:

1,4,6,7-tetrahydropyrano[4,3-c]pyrazole-3-carboxylic acid ethyl ester

Tetrahydro-4H-pyran-4-one

Refernces

• 1、 -. "Tricyclic azole derivatives". Page/Page column 18. . Retrieved 2010/11/24.