1-Benzoylpiperazine hydrochloride

Base Information

• Chemical Name: 1-Benzoylpiperazine hydrochloride
• CAS No.: 56227-55-5
• Molecular Formula: C₁₁H₁₄N₂O*ClH
• Molecular Weight: 226.706
• Hs Code.: 2933599090
• European Community (EC) Number: 625-340-2
• DSSTox Substance ID: DTXSID00480308
• Mol file: 56227-55-5.mol

Synonyms:1-Benzoylpiperazine hydrochloride;56227-55-5;1-BENZOYLPIPERAZINE HYROCHLORIDE 97;phenyl(piperazin-1-yl)methanone;hydrochloride;MFCD00459578;phenyl(piperazin-1-yl)methanone hydrochloride;1-BENZOYL-PIPERAZINE HCL;1-benzoylpiperazine HCl;1-benzoylpiperazine HCl salt;benzoylpiperazine hydrochloride;1-Benzoylpiperazinehydrochloride;SCHEMBL1597474;Methanone, phenyl-1-piperazinyl-, hydrochloride (1:1);DTXSID00480308;1-benzoylpiperazine hydro-chloride;KSVFXAZDBKITEF-UHFFFAOYSA-N;CS-M1666;AKOS015900532;1-BENZOYLPIPERAZINE HYROCHLORIDE;BS-4338;1-Benzoylpiperazine hydrochloride, 97%;1-BENZOYLPIPERAZINEHYROCHLORIDE97;phenylpiperazin-1-ylmethanone hydrochloride;FT-0701355;EN300-08796;phenyl-piperazine-1-yl-methanone hydrochloride;A853237;Z56953053;F1929-2096

Chemical Property of 1-Benzoylpiperazine hydrochloride

Chemical Property:

• Vapor Pressure: 7.34E-06mmHg at 25°C
• Melting Point: >230 °C(lit.)
• Boiling Point: 370.9°C at 760 mmHg
• Flash Point: 178.1°C
• PSA: 32.34000
• LogP: 1.80070
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 226.0872908
• Heavy Atom Count: 15
• Complexity: 194

Purity/Quality:

99.9% ^*data from raw suppliers

1-Benzoylpiperazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C(=O)C2=CC=CC=C2.Cl

Technology Process of 1-Benzoylpiperazine hydrochloride

There total 8 articles about 1-Benzoylpiperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester (77278-38-7) → N-benzoylpiperazine hydrochloride (56227-55-5,79332-89-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield: 63.0%

4-benzoyl-1-piperazinecarboxaldehyde (57238-77-4) → N-benzoylpiperazine hydrochloride (56227-55-5,79332-89-1)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 24h;

Reference yield:

1-benzoylimidazole (10364-94-0) + ethanol (64-17-5) + piperazine dihydrochloride (142-64-3,8006-71-1) → benzoic acid ethyl ester (93-89-0,99341-95-4) + 1,4-dibenzoylpiperazine (6091-41-4) + N-benzoylpiperazine hydrochloride (56227-55-5,79332-89-1) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With water;

DOI:10.1039/c1gc16314k

upstream raw materials:

4-benzoylpiperazine-1-carboxylic acid tert-butyl ester

1-benzoylimidazole

ethanol

piperazine dihydrochloride

Downstream raw materials:

2-(3-(4-benzoylpiperazino)propoxy)benzaldehyde

2-(2-(3-(4-benzoylpiperazino)propoxy)phenyl)-N-methylthiazolidine-3-carbthioamide

1-(4-benzoylpiperazin-1-yl)-2-(7-bromo-4-fluoro-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione

C₂₂H₁₇FN₆O₄

Refernces

• 1、 Adfeldt, Rebekka,Schmitz, Janna,Kropff, Barbara,Thomas, Marco,Monakhova, Natalia,H?lper, Julia E.,Klupp, Barbara G.,Mettenleiter, Thomas C.,Makarov, Vadim,Bogner, Elke. "Diazadispiroalkane derivatives are new viral entry inhibitors". supporting information. . Retrieved 2021/03/29.
• 2、 -. "C-3 NOVEL TRITERPENE WITH C-17 AMINE DERIVATIVES AS HIV INHIBITORS". Page/Page column 31; 32. . Retrieved 2017/09/15.