(3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride

Base Information

• Chemical Name: (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride
• CAS No.: 1311319-11-5
• Molecular Formula: C₂₅H₂₇F₃N₄O₆S*ClH
• Molecular Weight: 605.035
• Mol file: 1311319-11-5.mol

Synonyms:(3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride

Chemical Property of (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride

There total 6 articles about (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-tert-butyl 1-((S)-1-(2-((Z)-3-butylthiazolo[4,5-c]pyridin-2(3H)-ylidenecarbamoyl)-4-(trifluoromethyl)phenoxy)propan-2-yl) 2-(tert-butoxycarbonylamino)succinate (1311319-10-4) → (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride (1311319-11-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃;

Reference yield:

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide (1231955-35-3) → (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride (1311319-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

1.2: 4 h / 20 °C

2.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 20 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; HATU; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-fluoro-N-(thiazolo[4,5-c]pyridin-2-yl)-5-(trifluoromethyl)benzamide (1232169-35-5,1311319-13-7) → (3S)-4-({(1S)-2-[2-({[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]amino}carbonyl)-4-(trifluoromethyl)phenoxy]-1-methylethyl}oxy)-3-amino-4-oxobutanoic acid hydrochloride (1311319-11-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; tetra-(n-butyl)ammonium iodide; tetraethylammonium iodide / toluene / 12 h / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 20 °C

2.2: 4 h / 20 °C

3.1: dmap; triethylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: hydrogenchloride / ethyl acetate; 1,4-dioxane / 20 °C

With hydrogenchloride; dmap; tetraethylammonium iodide; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; HATU; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; toluene;

upstream raw materials:

2-fluoro-5-(trifluoromethyl)benzoic acid

2-fluoro-N-(thiazolo[4,5-c]pyridin-2-yl)-5-(trifluoromethyl)benzamide

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-fluoro-5-(trifluoromethyl)benzamide

N-[(2Z)-3-butyl[1,3]thiazolo[4,5-c]pyridin-2(3H)-ylidene]-2-{[(2S)-2-hydroxypropyl]oxy}-5-(trifluoromethyl)benzamide

Refernces