adenosine 5'-<α-thio>triphosphate

Base Information

• Chemical Name: adenosine 5'-<α-thio>triphosphate
• CAS No.: 29220-54-0
• Molecular Formula: C₁₀H₁₆N₅O₁₂P₃S
• Molecular Weight: 523.251
• Mol file: 29220-54-0.mol

Synonyms:adenosine 5'-<α-thio>triphosphate

Chemical Property of adenosine 5'-<α-thio>triphosphate

Chemical Property:

Purity/Quality:

≥99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of adenosine 5'-<α-thio>triphosphate

There total 4 articles about adenosine 5'-<α-thio>triphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H16N5O14P3S(4-) → adenosine 5'-<α-thio>triphosphate (29220-54-0)

Guidance literature:

With ammonia; In acetonitrile; at 20 ℃; for 6h;

DOI:10.1021/ol050617r

Reference yield:

2',3'-O,O-diacetyladenosine-5'-O-(2-thio-1,3,2-oxathiaphospholane) (857447-44-0) → adenosine 5'-<α-thio>triphosphate (29220-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent Spectr_. / DBU; tris(tetra-n-butylammonium) pyrophosphate / acetonitrile / 2 h

2: ammonia / acetonitrile / 6 h / 20 °C

With ammonia; tris(tetra-n-butylammonium) hydrogen pyrophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1021/ol050617r

Reference yield:

2',3'-di-O-acetyladenosine (29886-19-9) → adenosine 5'-<α-thio>triphosphate (29220-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / pyridine; sulfur / 16 h

2: 71 percent Spectr_. / DBU; tris(tetra-n-butylammonium) pyrophosphate / acetonitrile / 2 h

3: ammonia / acetonitrile / 6 h / 20 °C

With pyridine; ammonia; tris(tetra-n-butylammonium) hydrogen pyrophosphate; sulfur; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;

DOI:10.1021/ol050617r

upstream raw materials:

adenosine

2',3'-O,O-diacetyladenosine-5'-O-(2-thio-1,3,2-oxathiaphospholane)

2',3'-di-O-acetyladenosine

Downstream raw materials:

ATP

Refernces

• 1、 Goody, R. S.,Isakov, M.. "SIMPLE SYNTHESIS AND SEPARATION OF THE DIASTEREOMERS OF α-THIO ANALOGS OF RIBO- AND DEOXYRIBO- DI- AND TRIPHOSPHATES". . p. 3599 - 3602. Retrieved 2007/10/02.