2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN

Base Information

• Chemical Name: 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN
• CAS No.: 5631-96-9
• Molecular Formula: C7H13ClO2
• Molecular Weight: 164.632
• Hs Code.: 2932999099
• Mol file: 5631-96-9.mol

Synonyms:Pyran,2-(2-chloroethoxy)tetrahydro- (6CI,7CI);2-(2-Chloroethoxy)tetrahydro-2H-pyran;2-(2-Chloroethoxy)tetrahydropyran;2-Chloroethyl tetrahydropyranyl ether;2-[(Tetrahydropyran-2-yl)oxy]ethyl chloride;NSC 79867;

Chemical Property of 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN

Chemical Property:

• Vapor Pressure: 0.0986mmHg at 25°C
• Refractive Index: n20/D 1.459
• Boiling Point: 230.6 °C at 760 mmHg
• Flash Point: 87.8 °C
• PSA: 18.46000
• Density: 1.09 g/cm³
• LogP: 1.76840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Chloroethoxy)tetrahydro-2H-pyran ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN

There total 2 articles about 2-(2-CHLOROETHOXY)TETRAHYDRO-2H-PYRAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-chloro-ethanol (107-07-3) → 2-(2-chloroethoxy)-tetrahydro-2H-pyrane (5631-96-9)

Guidance literature:

With boron trichloride; In neat (no solvent); at 20 ℃; for 0.216667h; Green chemistry;

DOI:10.13005/ojc/330260

Reference yield:

→ 2-(2-chloroethoxy)-tetrahydro-2H-pyrane (5631-96-9)

Guidance literature:

Aus Tetrahydropyran m. Perbenzoesaeure-tert-butylester u. 2-Chlor-aethanol in Bzl. (CuCl; Siedetemp.);

Reference yield: 99.0%

2-(2-chloroethoxy)-tetrahydro-2H-pyrane (5631-96-9) → 2-methoxytetrahydropyran (6581-66-4) + 2-chloro-ethanol (107-07-3)

Guidance literature:

With methanol; DOWEX 50 W-X₂ cation exchange resin; at 40 ℃; for 1.33333h;

upstream raw materials:

3,4-dihydro-2H-pyran

2-chloro-ethanol

Downstream raw materials:

cyclohexylethan-1-ol

1-[2-(Tetrahydro-pyran-2-yloxy)-ethyl]-cyclohex-3-enecarbonitrile

(+/-)-2-(3-cyclohexenyl)ethanol

pentaethylene glycol

Refernces

• 1、 -. "Nitrogen heterocycle containing derivatives and application thereof in retinal diseases". Paragraph 0022; 0023; 0024. . Retrieved 2019/01/07.
• 2、 Trivedi, Evan R.,Blumenfeld, Carl M.,Wielgos, Todd,Pokropinski, Sharon,Dande, Prasad,Hai, Ton T.,Barrett, Anthony G.M.,Hoffman, Brian M.. "Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake". supporting information. p. 5475 - 5478. Retrieved 2013/01/13.