C₁₅H₂₁ClN₂O₂

Base Information

• Chemical Name: C₁₅H₂₁ClN₂O₂
• CAS No.: 1389330-74-8
• Molecular Formula: C₁₅H₂₁ClN₂O₂
• Molecular Weight: 296.797
• Mol file: 1389330-74-8.mol

Synonyms:C₁₅H₂₁ClN₂O₂

Chemical Property of C₁₅H₂₁ClN₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₂₁ClN₂O₂

There total 2 articles about C₁₅H₂₁ClN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-chloroacetyl-L-leucine (688-12-0) + p-toluidine (106-49-0,12221-03-3) → C15H21ClN2O2 (1389330-74-8)

Guidance literature:

N-chloroacetyl-L-leucine; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

p-toluidine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1002/cjoc.201201041

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → C15H21ClN2O2 (1389330-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 3 h / Reflux

2.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

2.2: 18 h / 20 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/cjoc.201201041

Reference yield: 85.0%

(S)-1-phenyl-ethylamine (2627-86-3) + C15H21ClN2O2 (1389330-74-8) → C23H31N3O2 (1389330-26-0)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; for 12h; Reflux;

DOI:10.1002/cjoc.201201041

upstream raw materials:

L-leucine

N-chloroacetyl-L-leucine

p-toluidine

Downstream raw materials:

C₄₃H₅₃N₅O₄

C₃₃H₅₂N₄O₆Si

C₂₃H₃₁N₃O₂

Refernces