6-ETHYL-4-HYDROXYCOUMARIN

Base Information

• Chemical Name: 6-ETHYL-4-HYDROXYCOUMARIN
• CAS No.: 55005-28-2
• Molecular Formula: C11H10O3
• Molecular Weight: 190.199
• Hs Code.: 2932209090
• Mol file: 55005-28-2.mol

Synonyms:6-ETHYL-4-HYDROXYCOUMARIN;6-ETHYL-4-HYDROXY-2H-CHROMEN-2-ONE;6-Ethyl-4-hydroxycoumarine

Chemical Property of 6-ETHYL-4-HYDROXYCOUMARIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 216-218°C
• Refractive Index: 1.62
• Boiling Point: 374.521°C at 760 mmHg
• Flash Point: 168.875°C
• PSA: 50.44000
• Density: 1.313g/cm³
• LogP: 2.06100

Purity/Quality:

98%Min ^*data from raw suppliers

6-Ethyl-4-hydroxycoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-ETHYL-4-HYDROXYCOUMARIN

There total 4 articles about 6-ETHYL-4-HYDROXYCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethyl-6-hydroxyacetophenone (24539-92-2) + Diethyl carbonate (105-58-8,76619-83-5) → 6-ethyl-4-hydroxycoumarin (55005-28-2)

Guidance literature:

With sodium hydride; In toluene; at 110 ℃;

DOI:10.1002/adsc.201300512

Reference yield:

4-Ethylphenol (123-07-9) + malonic acid (141-82-2) → 6-ethyl-4-hydroxycoumarin (55005-28-2)

Guidance literature:

With zinc(II) chloride; trichlorophosphate; at 70 ℃; for 10h;

DOI:10.21608/EJCHEM.2021.73699.3641

Reference yield:

→ 6-ethyl-4-hydroxycoumarin (55005-28-2) + 6-ethyl-4-hydroxy-3-nitro-chromen-2-one (55005-19-1)

Guidance literature:

upstream raw materials:

3-ethyl-6-hydroxyacetophenone

Diethyl carbonate

4-Ethylphenol

malonic acid

Downstream raw materials:

C₂₅H₁₉NO₂

7-ethyl-1,2,3,3-tetraphenylcyclopenta[b]chromen-9(3H)-one

Refernces

• 1、 Peng, Shiyong,Wang, Lei,Huang, Jiayao,Sun, Shaofa,Guo, Haibing,Wang, Jian. "Palladium-catalyzed oxidative annulation via C-H/N-H functionalization: Access to substituted pyrroles". supporting information. p. 2550 - 2557. Retrieved 2013/10/21.