(S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide

Base Information

• Chemical Name: (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide
• CAS No.: 223464-67-3
• Molecular Formula: C₄H₇F₃N₂O
• Molecular Weight: 156.108
• Mol file: 223464-67-3.mol

Synonyms:(S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide

Chemical Property of (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide

There total 2 articles about (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3,3-trifluoro-2-amino-2-methylpropionamide (122008-12-2) → (R)-(+)-3,3,3-trifluoro-2-amino-2-methylpropianoic acid (102210-02-6,55601-02-0) + (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropianoic acid (102210-03-7,55601-02-0) + (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide (223464-67-3)

Guidance literature:

With Klebsiella oxytoca amidase; In water; at 20 ℃;

DOI:10.1016/j.tet.2003.10.124

Reference yield:

3,3,3-trifluoro-2-amino-2-methylpropionamide (122008-12-2) → (R)-(+)-3,3,3-trifluoro-2-amino-2-methylpropianoic acid (102210-02-6,55601-02-0) + (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide (223464-67-3)

Guidance literature:

With amidase from Mycobacterium neoaurum; water; at 37 ℃; for 24h; pH=8.5;

DOI:10.2533/000942904777678127

Reference yield: 78.0%

N-Cbz-Ala (1142-20-7) + (S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide (223464-67-3) → [(S)-1-((S)-1-Carbamoyl-2,2,2-trifluoro-1-methyl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Guidance literature:

N-Cbz-Ala; With 4-methyl-morpholine; isobutyl chloroformate; In ethyl acetate; at -15 ℃; for 0.5h;

(S)-(-)-3,3,3-trifluoro-2-amino-2-methylpropionamide; In ethyl acetate; at -15 - 20 ℃;

DOI:10.1016/j.tetasy.2004.02.027

upstream raw materials:

3,3,3-trifluoro-2-amino-2-methylpropionamide

Refernces

• 1、 Blaauw, Richard H.,IJzendoorn, Denis R.,Cremers, Jozef G. O.,Rutjes, Floris P. J. T.,Broxterman, Quirinus B.,Schoemaker, Hans E.. "Chemo-enzymatic synthesis of chiral fluorine-containing building blocks". . p. 104 - 107. Retrieved 2007/10/03.