N-Acetyl-3-iodo-L-tyrosine, Amide

Base Information

• Chemical Name: N-Acetyl-3-iodo-L-tyrosine, Amide
• CAS No.: 59302-19-1
• Molecular Formula: C11H13IN2O3
• Molecular Weight: 348.14
• Mol file: 59302-19-1.mol

Synonyms:N-ACETYL-3-IODO-L-TYROSINE,AMIDE;N-Acetyl-3-iodo-L-tyrosinamid;

Chemical Property of N-Acetyl-3-iodo-L-tyrosine, Amide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 219-221°C
• Refractive Index: 1.638
• Boiling Point: 568.506°C at 760 mmHg
• Flash Point: 297.622°C
• PSA: 92.42000
• Density: 1.746g/cm³
• LogP: 1.62050

Purity/Quality:

98%min ^*data from raw suppliers

N-Acetyl-3-iodo-L-tyrosineAmide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Acetyl-3-iodo-L-tyrosine, Amide can be used in the synthesis of 3-iodo-L-thyronine and its iodinated derivatives

Technology Process of N-Acetyl-3-iodo-L-tyrosine, Amide

There total 1 articles about N-Acetyl-3-iodo-L-tyrosine, Amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetyl-3-iodo-L-tyrosine (1023-47-8) → N-Acetyl-3-iodo-L-tyrosinamid (59302-19-1)

Guidance literature:

Multistep reaction; (i) MeOH, TsOH, CH₂Cl₂, (ii) aq. NH₃;

DOI:10.1021/jm00230a018

Reference yield:

N-Acetyl-3-iodo-L-tyrosinamid (59302-19-1) → L-3,3'-Diiodothyronine (70-40-6,58342-32-8,4604-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaOEt, DMF, (ii) /BRN= 6464137/

2: aq. HBr, AcOH

3: I₂, aq. NH₃

With ammonium hydroxide; hydrogen bromide; iodine; acetic acid;

DOI:10.1021/jm00230a018

Reference yield:

N-Acetyl-3-iodo-L-tyrosinamid (59302-19-1) → L-3,3',5'-triiodothyronine (5817-39-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) NaOEt, DMF, (ii) /BRN= 6464137/

2: aq. HBr, AcOH

3: I₂, aq. NH₃

With ammonium hydroxide; hydrogen bromide; iodine; acetic acid;

DOI:10.1021/jm00230a018

upstream raw materials:

N-acetyl-3-iodo-L-tyrosine

Downstream raw materials:

(S)-2-Acetylamino-3-[3-iodo-4-(4-methoxy-phenoxy)-phenyl]-propionamide

3-Monoiodothyronine

L-3,3'-Diiodothyronine

L-3,3',5'-triiodothyronine

Refernces