2-Hydrazinylpyrazine

Base Information

• Chemical Name: 2-Hydrazinylpyrazine
• CAS No.: 54608-52-5
• Molecular Formula: C4H6N4
• Molecular Weight: 110.118
• Hs Code.: 29339900
• European Community (EC) Number: 689-669-3
• DSSTox Substance ID: DTXSID50363374
• Nikkaji Number: J1.734.112J
• Wikidata: Q72482868
• Mol file: 54608-52-5.mol

Synonyms:2-hydrazinylpyrazine;2-hydrazinopyrazine;54608-52-5;Pyrazin-2-yl-hydrazine;pyrazin-2-ylhydrazine;1-(pyrazin-2-yl)hydrazine;2(1H)-Pyrazinone, hydrazone;2-(Pyrazin-2-yl)hydrazine;1793001-76-9;hydrazino pyrazine;pyrazinyl hydrazine;3-hydrazinopyrazine;HYDRAZINOPYRAZINE;Pyrazin-2-yl hydrazine;1-(2-Pyrazinyl)hydrazine;2-Hydrazinopyrazine, 97%;SCHEMBL108576;DTXSID50363374;AMY11908;BCP24603;CS-M3641;BBL104189;STL558009;AKOS000126848;AC-7544;DS-1555;PB12798;BP-11967;A7925;FT-0647172;EN300-30894;10X-0803;J-509574;F8880-0110

Chemical Property of 2-Hydrazinylpyrazine

Chemical Property:

• Melting Point: 109-113℃
• Boiling Point: 307 °C at 760 mmHg
• PKA: 5.10±0.20(Predicted)
• Flash Point: 139.5 °C
• PSA: 63.83000
• Density: 1.334 g/cm³
• LogP: 0.53550
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 110.059246208
• Heavy Atom Count: 8
• Complexity: 65.1

Purity/Quality:

98%, ^*data from raw suppliers

2-Hydrazinopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-36/37/38
• Safety Statements: 26-39-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C=N1)NN
• Uses: Triazolo[4,3-a]pyrazine 7-oxide, 3-β-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, monohydrazones of pyridine, pyrazine, phenylglyoxal were synthesised from 2-Hydrazinopyrazine.

Technology Process of 2-Hydrazinylpyrazine

There total 2 articles about 2-Hydrazinylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

2-chloropyrazin (14508-49-7) → 2-hydrazinylpyrazine (54608-52-5)

Guidance literature:

With hydrazine hydrate; sodium carbonate; at 120 - 130 ℃;

DOI:10.1080/10426507.2019.1577845

Reference yield:

→ 2-hydrazinylpyrazine (54608-52-5)

Guidance literature:

DOI:10.1039/j39660002038 DOI:10.1021/jm00197a007

Reference yield: 95.0%

4-methoxy-benzaldehyde (123-11-5) + 2-hydrazinylpyrazine (54608-52-5) → 3-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:

With toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; at 80 ℃; for 1h;

DOI:10.24820/ark.5550190.p010.696

upstream raw materials:

2-chloropyrazin

Downstream raw materials:

3-Methyl-s-triazolo<4,3-a>pyrazin

ethyl 1-(pyrazin-2-yl)-1H-pyrazole-4-carboxylate

2-[5-(4-Fluorophenyl)-3-(1-methylethyl)-1H-pyrazol-1-yl]pyrazine

3-(5-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<4,3-a>pyrazine

Refernces

• 1、 Lee, Jae Chul,Hong, Kwon Ho,Becker, Andreas,Tash, Joseph S.,Sch?nbrunn, Ernst,Georg, Gunda I.. "Tetrahydroindazole inhibitors of CDK2/cyclin complexes". . . Retrieved 2021/02/09.
• 2、 Mannam, Madhava Rao,Devineni, Subba Rao,Pavuluri, Chandra Mouli,Chamarthi, Naga Raju,Kottapalli, Raja Sekhara P.. "Urea and thiourea derivatives of 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1, 2, 4]triazolo[4,3-a]pyrazine: Synthesis, characterization, antimicrobial activity and docking studies". . p. 922 - 932. Retrieved 2019/03/07.