Technology Process of 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione
There total 20 articles about 1-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-3-ethylimidazolidine-2,4-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-ethyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)imidazolidine-2,4-dione; (2S,3R,4S,5R)-2-(3-(bromomethyl)-4-chlorophenyl)-3,4,5-tris(methoxymethoxy)-6-((methoxymethoxy)methyl)tetrahydro-2H-pyran;
With
sodium carbonate;
palladium;
In
water; N,N-dimethyl-formamide;
at 80 ℃;
for 4h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / tetrahydrofuran / 5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C
2.1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 2 h / 0 °C
3.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / dichloromethane / 24 h / 0 - 20 °C
3.2: 0 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 - 20 °C
5.1: triethylamine; methanesulfonyl chloride / ethyl acetate; toluene / 2 h / 0 °C
5.2: 1 h / 0 - 20 °C
6.1: sodium carbonate / palladium / N,N-dimethyl-formamide; water / 4 h / 80 °C / Inert atmosphere
6.2: 20 °C
With
triethylsilane; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; sodium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;