O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL

Base Information

• Chemical Name: O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL
• CAS No.: 58138-78-6
• Molecular Formula: C10H19FN2O2Si2
• Molecular Weight: 274.442
• Mol file: 58138-78-6.mol

Synonyms:O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL;BIS(TRIMETHYLSILYL)-5-FLUOROURACIL;2,4-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL

Chemical Property of O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL

Chemical Property:

• PSA: 58.20000
• LogP: 4.65760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL

There total 4 articles about O,O'-BIS(TRIMETHYLSILYL)-5-FLUOROURACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ bis-trimethylsilyl-5-fluoro-uracil (58138-78-6)

Guidance literature:

Reference yield:

5-fluorouracil (51-21-8) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → bis-trimethylsilyl-5-fluoro-uracil (58138-78-6)

Guidance literature:

With ammonium sulfate; for 1h; Heating;

Reference yield:

5-fluorouracil (51-21-8) + N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) → bis-trimethylsilyl-5-fluoro-uracil (58138-78-6)

Guidance literature:

In acetonitrile;

DOI:10.1021/jo902485m

upstream raw materials:

5-fluorouracil

1,1,1,3,3,3-hexamethyl-disilazane

N,O-bis-(trimethylsilyl)-acetamide

Downstream raw materials:

Benzoic acid 2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester

1-[[2-benzyloxy-1-(benzyloxymethyl)-ethoxy]methyl]-5-fluorouracil

5-fluoro-1-(trans-3'-fluoro-2',3',4',5'-tetrahydro-2'-furanyl)uracil

(+/-)-5-fluoro-1-((2'R,3'S)-3'-fluorotetrahydrofuran-2'-yl)pyrimidine-2,4(1H,3H)-dione

Refernces

• 1、 Piperno, Anna,Giofre, Salvatore V.,Iannazzo, Daniela,Romeo, Roberto,Romeo, Giovanni,Chiacchio, Ugo,Rescifina, Antonio,Piotrowska, Dorota G.. "Synthesis of C-4′Truncated Phosphonated Carbocyclic 2′-Oxa-3′-azanucleosides as Antiviral Agents". experimental part. p. 2798 - 2805. Retrieved 2010/07/17.
• 2、 -. "Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same". . . Retrieved 2008/06/13.