(S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine

Base Information

• Chemical Name: (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine
• CAS No.: 141294-38-4
• Molecular Formula: C₁₄H₂₃N
• Molecular Weight: 205.343
• Mol file: 141294-38-4.mol

Synonyms:(S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine

Chemical Property of (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine

There total 12 articles about (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,3-dimethyl-butan-2-one (75-97-8) + (S)-1-phenyl-ethylamine (2627-86-3) → (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine (141294-38-4)

Guidance literature:

3,3-dimethyl-butan-2-one; (S)-1-phenyl-ethylamine; With tris(pentafluorophenyl)borate; In toluene; at 60 ℃; for 8h; Molecular sieve;

With ammonia borane; In toluene; at 0 ℃; for 12h; diastereoselective reaction; Molecular sieve;

DOI:10.1021/acs.joc.8b01362

Reference yield: 91.0%

C14H21N → (S,S)-N-(1,2,2-trimethylpropyl)phenylethyl-1-amine α-methylbenzylamine (141294-38-4)

Guidance literature:

With borane-ammonia complex; at 30 ℃; for 6h;

Reference yield: 82.0%

N-<3,3-Dimethyl-butyliden-(2)>-DL-α-phenyl-ethylamin (31519-48-9,31519-49-0,33978-33-5,141393-92-2,141393-93-3,18805-16-8) → Trimethyl-1,2,2-propyl-phenylaethylamin (141294-37-3,141294-38-4,25102-90-3)

Guidance literature:

N-<3,3-Dimethyl-butyliden-(2)>-DL-α-phenyl-ethylamin; In methanol; at 20 ℃;

With sodium tetrahydroborate; sodium hydroxide; In methanol; water; at 40 - 60 ℃; for 2h;

DOI:10.1080/00397911.2011.562063

upstream raw materials:

N-<3,3-Dimethyl-butyliden-(2)>-DL-α-phenyl-ethylamin

(S)-α-methyl-N-(1,2,2-trimethylpropylidene)benzenemethanamine

3,3-dimethyl-butan-2-one

(S)-1-phenyl-ethylamine

Downstream raw materials:

(S)-1,2,2-trimethylpropylamine

Refernces

• 1、 -. "Preparation method of chiral amine compounds". . . Retrieved 2018/09/13.
• 2、 Heiden, Zachariah M.,Stephan, Douglas W.. "Metal-free diastereoselective catalytic hydrogenations of imines using B(C6F5)3". . p. 5729 - 5731. Retrieved 2011/07/08.