4-chloro-3-sulfamoylbenzonitrile

Base Information

• Chemical Name: 4-chloro-3-sulfamoylbenzonitrile
• CAS No.: 1939-76-0
• Molecular Formula: C₇H₅ClN₂O₂S
• Molecular Weight: 216.648
• Mol file: 1939-76-0.mol

Synonyms:4-chloro-3-sulfamoylbenzonitrile

Chemical Property of 4-chloro-3-sulfamoylbenzonitrile

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-3-sulfamoylbenzonitrile

There total 9 articles about 4-chloro-3-sulfamoylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-chloro-3-sulfamoylbenzamide (2455-92-7) → 4-chloro-3-sulfamoylbenzonitrile (1939-76-0)

Guidance literature:

4-chloro-3-sulfamoylbenzamide; With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; Cooling;

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

DOI:10.1021/jm301743b

Reference yield:

C9H4ClF3N2O3S → 4-chloro-3-sulfamoylbenzonitrile (1939-76-0)

Guidance literature:

C₉H₄ClF₃N₂O₃S; With sodium hydroxide; In water; at 0 ℃;

With hydrogenchloride; In water; pH=6.5;

Reference yield:

3-(aminosulfonyl)-4-chlorobenzoyl chloride (70049-77-3) → 4-chloro-3-sulfamoylbenzonitrile (1939-76-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium hydroxide / 1,4-dioxane / 0.5 h

2.1: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / Cooling

2.2: 0.5 h / 20 °C

With ammonium hydroxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm301743b

upstream raw materials:

4-chloro-3-sulphamoylbenzoic acid

4-chloro-3-sulfamoylbenzamide

3-(aminosulfonyl)-4-chlorobenzoyl chloride

4-Cyanochlorobenzene

Downstream raw materials:

2-chloro-5-formyl-benzenesulphonamide

C₁₆H₇Cl₂F₃N₄O₃S

4-chloro-3-sulfamoylphenyl-2-methyl-3-indolyl-ketonimine hydrochloride

5-cyano-2-(4-methyl-piperazin-1-yl)-benzenesulfonamide

Refernces

• 1、 Pirotte, Bernard,De Tullio, Pascal,Florence, Xavier,Goffin, Eric,Somers, Fabian,Boverie, Stéphane,Lebrun, Philippe. "1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action". . p. 3247 - 3256. Retrieved 2013/06/05.