Urea, C-14

Base Information

• Chemical Name: Urea, C-14
• CAS No.: 594-05-8
• Molecular Formula: CH4N2O
• Molecular Weight: 62.0446
• UNII: WBZ6M63TEE
• ChEMBL ID: CHEMBL2096635
• DSSTox Substance ID: DTXSID701026303
• NCI Thesaurus Code: C47780
• Nikkaji Number: J3.165.202B
• RXCUI: 253158
• Wikidata: Q27098010
• Mol file: 594-05-8.mol

Synonyms:Urea-14C;UREA, C-14;Urea C-14;14C-urea;UREA C 14;Pytest;carbon 14 urea;Urea ((sup 14)C);594-05-8;carbon-14 urea;Urea (14C);diamino(114C)methanone;Urea 14 C;UNII-WBZ6M63TEE;WBZ6M63TEE;Urea C 14 [USP];Pytest (TN);Urea C14 (USP);CHEMBL2096635;UREA 14 C [WHO-DD];UREA, [14C];CHEBI:134711;DTXSID701026303;UREA C 14 [USP IMPURITY];UREA, C-14 [ORANGE BOOK];DB09513;D10496;Q27098010

Chemical Property of Urea, C-14

Chemical Property:

• PSA: 69.11000
• LogP: 0.42440
• Storage Temp.: 2-8°C
• XLogP3: -1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 62.03560474
• Heavy Atom Count: 4
• Complexity: 29

Purity/Quality:

99% ^*data from raw suppliers

UREA[14C] 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: R,Xn
• Statements: 36/37/38-40
• Safety Statements: 22-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(=O)(N)N
• Isomeric SMILES: [14C](=O)(N)N

Technology Process of Urea, C-14

There total 8 articles about Urea, C-14 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[14C]cyanamide (21420-36-0) → [14C]urea (594-05-8)

Guidance literature:

With sulfuric acid; In not given; sublimation in vac. at 60 until 70°C at 0.01 Torr; recrystn. from isoamyl alcohol at -30°C then from acetone at -40°C;

DOI:10.1021/ja01174a091

Reference yield:

→ [14C]urea (594-05-8)

Guidance literature:

With sulfuric acid; at 40 ℃; Hydrolysis;

DOI:10.1021/ja01174a091

Reference yield:

barium <14 C>cyanamide → [14C]urea (594-05-8)

Guidance literature:

With sulfuric acid; at 50 ℃; for 4h;

DOI:10.1002/(SICI)1099-1344(199912)42:12<1203::AID-JLCR276>3.0.CO;2-F

upstream raw materials:

[14C]carbon dioxide

urea

[¹⁴C]cyanamide

potassium [¹⁴C]cyanate

Downstream raw materials:

potassium [¹⁴C]cyanate

<2-(14)C>uracil

urea

methyl 4-(4-fluorophenyl)-6-isopropyl-2-[⁽¹⁴⁾C]-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Refernces

• 1、 Terzuoli, Lucia,Porcelli, Brunetta,Ponticelli, Fabio,Marinello, Enrico. "Purine nucleotide catabolism in rat liver. Certain preliminary aspects of uricase reaction". . p. 193 - 203. Retrieved 2009.
• 2、 Lafont,Lambrey,D'Athis,et al.. "In vivo and in vitro studies of urea formation from a ω-1 hydroxybarbiturate: Proxibarbal". . p. 181 - 186. Retrieved 2007/10/02.