Technology Process of (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxy-4-methoxyphenyl)acetic acid
There total 27 articles about (R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dihydroxy-4-methoxyphenyl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
DOI:10.1021/jo972076s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C
1.2: 1.5 h / 20 - 50 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 0 °C
3.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); XPhos; potassium acetate / tetrahydrofuran / 1 h / 75 °C / Inert atmosphere; Sealed tube
4.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 45 °C / Inert atmosphere; Sealed tube
5.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C / Inert atmosphere
With
lithium hydroxide monohydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); dihydrogen peroxide; potassium acetate; caesium carbonate; sodium hydroxide; XPhos;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
3.1: |Miyaura Borylation Reaction;
DOI:10.1021/jacs.0c07433
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuryl dichloride / sulfolane / 0.5 h / 30 - 60 °C
2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C
2.2: 1.5 h / 20 - 50 °C
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.25 h / 0 °C
4.1: chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); XPhos; potassium acetate / tetrahydrofuran / 1 h / 75 °C / Inert atmosphere; Sealed tube
5.1: dihydrogen peroxide / tetrahydrofuran; water / 2 h / 45 °C / Inert atmosphere; Sealed tube
6.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 2 h / 0 - 20 °C / Inert atmosphere
With
sulfuryl dichloride; lithium hydroxide monohydrate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); dihydrogen peroxide; potassium acetate; caesium carbonate; sodium hydroxide; XPhos;
In
tetrahydrofuran; 1,4-dioxane; sulfolane; water; N,N-dimethyl-formamide;
4.1: |Miyaura Borylation Reaction;
DOI:10.1021/jacs.0c07433