3,3-dichlorocyclobutanecarbonitrile

Base Information

• Chemical Name: 3,3-dichlorocyclobutanecarbonitrile
• CAS No.: 27744-70-3
• Molecular Formula: C₅H₅Cl₂N
• Molecular Weight: 150.007
• Mol file: 27744-70-3.mol

Synonyms:3,3-dichlorocyclobutanecarbonitrile

Chemical Property of 3,3-dichlorocyclobutanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3,3-dichlorocyclobutanecarbonitrile

There total 2 articles about 3,3-dichlorocyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-oxo-cyclobutanecarbonitrile (20249-16-5) → 3,3-dichlorocyclobutanecarbonitrile (27744-70-3)

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane;

DOI:10.1021/ja00730a021

Reference yield:

3-methylenecyclobutanecarbonitrile (15760-35-7) → 3,3-dichlorocyclobutanecarbonitrile (27744-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaIO₄, OsO₄ / H₂O; diethyl ether

2: PCl₅ / CCl₄

With sodium periodate; osmium(VIII) oxide; phosphorus pentachloride; In tetrachloromethane; diethyl ether; water;

DOI:10.1021/ja00730a021

Reference yield:

3,3-dichlorocyclobutanecarbonitrile (27744-70-3) → 3-chlorobicyclobutane-1-carbonitrile (23745-75-7)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; at 30.4 - 50.2 ℃; Thermodynamic data; Rate constant; 1,3-dehydrohalogenation, ΔH(excit.), ΔS(excit.);

DOI:10.1021/ja00258a038

upstream raw materials:

3-oxo-cyclobutanecarbonitrile

3-methylenecyclobutanecarbonitrile

Downstream raw materials:

3-chlorobicyclobutane-1-carbonitrile