2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI)
• CAS No.: 471909-54-3
• Molecular Formula: C6H5FN2O
• Molecular Weight: 0
• Mol file: 471909-54-3.mol

Synonyms:2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI)

Chemical Property of 2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI)

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

3-fluoro-2-Pyridinecarboxaldehydeoxime 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI)

There total 8 articles about 2-Pyridinecarboxaldehyde,3-fluoro-,oxime(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-fluoropyridine-2-carbaldehyde (31224-43-8) → 3-fluoropyridine-2-carbaldehyde oxime (471909-54-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; Reflux;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

2-Amino-6-methylpyridine (1824-81-3) → 3-fluoropyridine-2-carbaldehyde oxime (471909-54-3)

Guidance literature:

Multi-step reaction with 8 steps

1: sulfuric acid; nitric acid

2: hydrogenchloride; sodium nitrite

3: phosphorus pentachloride; trichlorophosphate

4: palladium on carbon; hydrogen

5: tetrafluoroboric acid; ethyl nitrite

6: iodine; potassium acetate / acetic anhydride

7: ozone

8: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / Reflux

With hydrogenchloride; tetrafluoroboric acid; ethyl nitrite; phosphorus pentachloride; sulfuric acid; palladium on carbon; hydroxylamine hydrochloride; hydrogen; iodine; nitric acid; potassium acetate; ozone; sodium hydroxide; sodium nitrite; trichlorophosphate; In ethanol; water; acetic anhydride; 5: Balz-Schiemann reaction;

DOI:10.1016/j.jfluchem.2011.05.028

Reference yield:

2-methyl-3-pyridinamine (3430-10-2) → 3-fluoropyridine-2-carbaldehyde oxime (471909-54-3)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrafluoroboric acid; ethyl nitrite

2: iodine; potassium acetate / acetic anhydride

3: ozone

4: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / Reflux

With tetrafluoroboric acid; ethyl nitrite; hydroxylamine hydrochloride; iodine; potassium acetate; ozone; sodium hydroxide; In ethanol; water; acetic anhydride; 1: Balz-Schiemann reaction;

DOI:10.1016/j.jfluchem.2011.05.028

upstream raw materials:

2-Amino-6-methylpyridine

2-methyl-3-pyridinamine

C₁₃H₁₀FN

6-chloro-4-methyl-3-nitropyridine

Refernces

• 1、 Timperley, Christopher M.,Banks, R. Eric,Young, Ian M.,Haszeldine, Robert N.. "Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning". . p. 541 - 547. Retrieved 2011/09/15.