(3R)-3-AMINOPENTANENITRILE METHANESULFONATE

Base Information

• Chemical Name: (3R)-3-AMINOPENTANENITRILE METHANESULFONATE
• CAS No.: 474645-97-1
• Molecular Formula: C6H14N2O3S
• Molecular Weight: 194.25
• Mol file: 474645-97-1.mol

Synonyms:(R)-3-Aminopentanenitrile methanesulfonic acid salt;(3R)-3-Aminopentanenitrile methanesulfonate;

Chemical Property of (3R)-3-AMINOPENTANENITRILE METHANESULFONATE

Chemical Property:

• Boiling Point: 414.7 °C at 760 mmHg
• Flash Point: 204.6 °C
• PSA: 112.56000
• LogP: 1.92248
• Solubility.: Dimethylformamide, DMSO

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-AminopentanenitrileMethanesulfonicAcidSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of quinolines.

Technology Process of (3R)-3-AMINOPENTANENITRILE METHANESULFONATE

There total 5 articles about (3R)-3-AMINOPENTANENITRILE METHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

(R)-3-aminopentanenitrile-dibenzoyl-(L)-tartrate salt + methanesulfonic acid (75-75-2,98527-29-8) → (R)-3-aminopentanenitrile methanesulfonic acid salt (474645-97-1)

Guidance literature:

In ethyl acetate; at 20 - 70 ℃;

Reference yield: 81.0%

methanesulfonic acid (75-75-2,98527-29-8) + (R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile (198493-28-6) → (R)-3-aminopentanenitrile methanesulfonic acid salt (474645-97-1)

Guidance literature:

In tetrahydrofuran; at 40 - 65 ℃; for 6.5h;

DOI:10.1021/op060013i

Reference yield: 59.0%

methanesulfonic acid (75-75-2,98527-29-8) + (R)-3-aminopentanenitrile (400090-60-0) → (R)-3-aminopentanenitrile methanesulfonic acid salt (474645-97-1)

Guidance literature:

In ethyl acetate; at 20 ℃; for 16h;

upstream raw materials:

methanesulfonic acid

(R)-3-aminopentanenitrile

(R)-N-tert-butyloxycarbonyl-3-aminopentanenitrile

Downstream raw materials:

(R)-3-aminopentanenitrile

(2R,4S)-(2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamic acid methyl ester

(R)-3-((4-(trifluoromethyl)phenyl)amino)pentanenitrile

C₃₀H₃₃F₉N₆O₂

Refernces

• 1、 -. "BIOCATALYTIC PREPARATION OF ENANTIOMERICALLY ENRICHED AMINOPENTANENITRILE". Page 22. . Retrieved 2010/02/07.
• 2、 -. "Method for optical resolution of 3-aminopentanenitrile". Page 7. . Retrieved 2008/06/13.