2-amino-N-cyclopropylacetamide

Base Information

• Chemical Name: 2-amino-N-cyclopropylacetamide
• CAS No.: 120436-02-4
• Molecular Formula: C₅H₁₀N₂O
• Molecular Weight: 114.147
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40407155
• Wikidata: Q82212395
• Mol file: 120436-02-4.mol

Synonyms:2-amino-N-cyclopropylacetamide;120436-02-4;2-amino-N-cyclopropyl-acetamide;N-cyclopropylglycinamide;N1-Cyclopropylglycinamide;SCHEMBL3135300;DTXSID40407155;2-azanyl-N-cyclopropyl-ethanamide;CAYSWNDCZRTXGL-UHFFFAOYSA-N;MFCD06658308;AKOS000206339;SB31704;2-amino-N-cyclopropyl-acetamide, AldrichCPR;CS-0110031;FT-0733239;EN300-35428;D76973;A804506;A804603;F2158-0297

Chemical Property of 2-amino-N-cyclopropylacetamide

Chemical Property:

• Vapor Pressure: 0.000609mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 310.2°C at 760 mmHg
• Flash Point: 141.4°C
• PSA: 55.12000
• Density: 1.11g/cm³
• LogP: 0.31490
• Storage Temp.: 2-8°C
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 114.079312947
• Heavy Atom Count: 8
• Complexity: 98.6

Purity/Quality:

98%Min ^*data from raw suppliers

2-Amino-n-cyclopropyl-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NC(=O)CN
• Uses: 2-Amino-n-cyclopropyl-acetamide is a reagent used in the preparation of (aminomethylaryl-oxoquinazolinyl)acetamide Vasopressin V1b receptor antagonist.

Technology Process of 2-amino-N-cyclopropylacetamide

There total 1 articles about 2-amino-N-cyclopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-carbobenzyloxyglycine cyclopropylamide (120436-01-3) → 2-amino-N-cyclopropylacetamide (120436-02-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 16h; under 1551.44 Torr;

DOI:10.1021/jm050394a

Reference yield: 64.0%

2-amino-N-cyclopropylacetamide (120436-02-4) + 4-chloro-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)-5-phenylpyrrolo[2,3-d]pyrimidine (871671-47-5) → 4-N-(N-cyclopropylcarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine (871671-59-9)

Guidance literature:

In butan-1-ol; for 30h; Heating;

DOI:10.1021/jm050394a

Reference yield:

2-amino-N-cyclopropylacetamide (120436-02-4) → N-cyclopropyl-2-[7-(3,4-dihydroxy-5-methyl-tetrahydro-furan-2-yl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / butan-1-ol / 30 h / Heating

2: 94 percent / aq. TFA / 2 h / 20 °C

With trifluoroacetic acid; In butan-1-ol;

DOI:10.1021/jm050394a

upstream raw materials:

N-carbobenzyloxyglycine cyclopropylamide

Downstream raw materials:

4-N-(N-cyclopropylcarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

4-N-(N-cyclopropylthionocarbamoylmethyl)amino-5-phenyl-7-(5-deoxy-2,3-O-isopropylidenyl-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine

C₂₉H₂₈N₄O₂

Refernces