2-iodoisophthalaldehyde

Base Information

• Chemical Name: 2-iodoisophthalaldehyde
• CAS No.: 777854-97-4
• Molecular Formula: C₈H₅IO₂
• Molecular Weight: 260.031
• Mol file: 777854-97-4.mol

Synonyms:2-iodoisophthalaldehyde

Chemical Property of 2-iodoisophthalaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-iodoisophthalaldehyde

There total 2 articles about 2-iodoisophthalaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-iodo-1,3-benzenedicarbonitrile (81725-16-8) → 2-iodoisophthalaldehyde (777854-97-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; cyclohexane; at -25 - 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1039/d1cc03097c

Reference yield:

benzene-1,3-dicarbonitrile (626-17-5) → 2-iodoisophthalaldehyde (777854-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; 2-methyltetrahydrofuran; n-heptane; ethylbenzene / 0.25 h / -90 °C / Inert atmosphere

1.2: -90 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / -78 - 0 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

2.3: 0.25 h / Cooling with ice; Inert atmosphere

With diisobutylaluminium hydride; lithium diisopropyl amide; In tetrahydrofuran; 2-methyltetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; toluene;

DOI:10.1016/j.tetasy.2010.12.002

Reference yield: 100.0%

2-iodoisophthalaldehyde (777854-97-4) + (1R,2R)-N-allyl-1,2-diphenylethylenediamine (1268872-76-9) → C42H41IN4

Guidance literature:

In toluene; for 16h; Inert atmosphere; Molecular sieve;

DOI:10.1016/j.tetasy.2010.12.002

upstream raw materials:

benzene-1,3-dicarbonitrile

2-iodo-1,3-benzenedicarbonitrile

Downstream raw materials:

2,6-di[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]-1-hexylbenzene

2,6-di-[(4R,5R)-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl]iodobenzene

2,6-di[(4R,5R)-4,5-di-tert-butyl-4,5-dihydro-1H-imidazol-2-yl]iodobenzene

2,6-di[(4R,5R)-4,5-dimesityl-4,5-dihydro-1H-imidazol-2-yl]iodobenzene

Refernces

• 1、 Arai, Takayoshi,Suzuki, Takumi,Inoue, Takahiro,Kuwano, Satoru. "Chiral Bis(imidazolidine)iodobenzene (I-Bidine) Organocatalyst for Thiochromane Synthesis Using an Asymmetric Michael/Henry Reaction". . p. 122 - 127. Retrieved 2016/12/26.