2-Thiopheneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)

Base Information

• Chemical Name: 2-Thiopheneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)
• CAS No.: 120450-98-8
• Molecular Formula: C6H4 Cl N O2 S
• Molecular Weight: 189.622
• Mol file: 120450-98-8.mol

Synonyms:N-Hydroxy-a-oxo-2-thiopheneethanimidoylchloride

Chemical Property of 2-Thiopheneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)

Chemical Property:

• PSA: 77.90000
• LogP: 1.95730

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiopheneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)

There total 2 articles about 2-Thiopheneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-oxo-2-(thiophen-2-yl)acetaldehyde oxime (128694-37-1) → α-oxo-α-(2-thienyl)acetohydroximoyl chloride (120450-98-8)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1021/acsmedchemlett.0c00443

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → α-oxo-α-(2-thienyl)acetohydroximoyl chloride (120450-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; tert.-butylnitrite / 1,4-dioxane / 1 h / 0 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; tert.-butylnitrite; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.0c00443

Reference yield: 95.0%

3-hydroxy-1-(5-methyl-1-phenyl-1H-1,2,3-triazole-4-yl)prop-2-en-1-one sodium salt + α-oxo-α-(2-thienyl)acetohydroximoyl chloride (120450-98-8) → (5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)(3-(thiophene-2-carbonyl)isoxazol-4-yl)methanone

Guidance literature:

With sodium carbonate; In neat (no solvent); at 20 ℃; for 0.25h; Green chemistry;

DOI:10.1002/jhet.2343

upstream raw materials:

2-Acetylthiophene

2-oxo-2-(thiophen-2-yl)acetaldehyde oxime

Downstream raw materials:

[4-(8,9-dimethoxy-1-phenyl-1,5,6,10b-tetrahydro[1,2,4]-triazolo[3,4-a]isoquinoline-3-carbonyl)isoxazol-3-yl]-(2-thienyl)methanone

[4-(8,9-dimethoxy-1-(4-methylphenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl](2-thienyl)methanone

[4-(8,9-dimethoxy-1-(4-chlorophenyl)-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinoline-3-carbonyl)-isoxazol-3-yl](2-thienyl)methanone

1,5-diphenyl-3-[3-(thienyl-2-carbonyl)-isoxazole-4-carbonyl]-1H-pyrazole-4-carbonitrile

Refernces