C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE

Base Information

• Chemical Name: C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE
• CAS No.: 120740-10-5
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.039
• Hs Code.: 2933399090
• Mol file: 120740-10-5.mol

Synonyms:C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE;5-Aminomethyl-2-bromopyridine;3-Pyridinemethanamine,6-bromo;(2-Bromo-5-pyridyl)methylamine;(6-Bromopyridin-3-yl)methylamine;

Chemical Property of C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE

Chemical Property:

• Vapor Pressure: 0.00211mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 290.1 °C at 760 mmHg
• PKA: 7.74±0.29(Predicted)
• Flash Point: 129.3 °C
• PSA: 38.91000
• Density: 1.574 g/cm³
• LogP: 2.00310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

5-Aminomethyl-2-bromopyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE

There total 4 articles about C-(6-BROMO-PYRIDIN-3-YL)-METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-bromo-5-cyanopyridine (139585-70-9) → C-(6-bromopyridin-3-yl)methylamine (120740-10-5)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 20 ℃; for 17h;

Reference yield: 40.0%

2-bromo-5-bromomethylpyridine (101990-45-8) → C-(6-bromopyridin-3-yl)methylamine (120740-10-5)

Guidance literature:

2-bromo-5-bromomethylpyridine; With hexamethylenetetramine; In chloroform; at 20 ℃; for 16h;

With ammonium hydroxide; In water; for 1.5h; Reflux;

With formaldehyd; In water; at 20 ℃;

Reference yield:

C14H9BrN2O2 (120740-11-6) → C-(6-bromopyridin-3-yl)methylamine (120740-10-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1021/jf072851x

upstream raw materials:

C₁₄H₉BrN₂O₂

2-Bromo-5-methylpyridine

2-bromo-5-bromomethylpyridine

2-bromo-5-cyanopyridine

Downstream raw materials:

N²-(4-aminocyclohexyl)-N⁶-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamine

N²-(4-aminocyclohexyl)-9-cyclopentyl-N⁶-(6-furan-2-yl-pyridin-3-ylmethyl)-9H-purine-2,6-diamine

N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

N²-(4-aminocyclohexyl)-N⁶-[6-(2-aminophenyl)pyridin-3-ylmethyl]-9-cyclopentyl-9H-purine-2,6-diamine

Refernces

• 1、 -. "2-SUBSTITUTED-6-BIARYLMETHYLAMINO-9-CYCLOPENTYL-9H-PURINE DERIVATIVES, USE THEREOF AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS". Paragraph 0089. . Retrieved 2016/03/08.
• 2、 Liu, Yu-Xiu,Wei, Deng-Guo,Zhu, Ye-Rong,Liu, Shao-Hua,Zhang, Yong-Lin,Zhao, Qi-Qi,Cai, Bao-Li,Li, Yong-Hong,Song, Hai-Bin,Liu, Ying,Wang, Yong,Huang, Run-Qiu,Wang, Qing-Min. "Synthesis, herbicidal activities, and 3D-QSAR of 2-cyanoacrylates containing aromatic methylamine moieties". experimental part. p. 204 - 212. Retrieved 2009/04/11.