4-iodo-5-chloro-2-methoxybenzonitrile

Base Information

• Chemical Name: 4-iodo-5-chloro-2-methoxybenzonitrile
• CAS No.: 1057339-09-9
• Molecular Formula: C₈H₅ClINO
• Molecular Weight: 293.491
• Mol file: 1057339-09-9.mol

Synonyms:4-iodo-5-chloro-2-methoxybenzonitrile

Chemical Property of 4-iodo-5-chloro-2-methoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-iodo-5-chloro-2-methoxybenzonitrile

There total 4 articles about 4-iodo-5-chloro-2-methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-5-chloro-2-methoxybenzonitrile (31380-91-3) → 4-iodo-5-chloro-2-methoxybenzonitrile (1057339-09-9)

Guidance literature:

Reference yield:

4-amino-5-chloro-2-methoxybenzoic acid (7206-70-4) → 4-iodo-5-chloro-2-methoxybenzonitrile (1057339-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfonamide; pyridine / 2.5 h / Inert atmosphere; Heating

2.1: trichlorophosphate / acetonitrile / 3 h / 80 °C

3.1: hydrogenchloride; sodium nitrite / water; acetic acid / 0.5 h / 5 °C

3.2: 1.5 h

With pyridine; hydrogenchloride; sulfonamide; sodium nitrite; trichlorophosphate; In water; acetic acid; acetonitrile;

DOI:10.1016/j.bmc.2012.08.050

Reference yield:

4-amino-5-chloro-2-methoxybenzamide (24190-74-7) → 4-iodo-5-chloro-2-methoxybenzonitrile (1057339-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trichlorophosphate / acetonitrile / 3 h / 80 °C

2.1: hydrogenchloride; sodium nitrite / water; acetic acid / 0.5 h / 5 °C

2.2: 1.5 h

With hydrogenchloride; sodium nitrite; trichlorophosphate; In water; acetic acid; acetonitrile;

DOI:10.1016/j.bmc.2012.08.050

upstream raw materials:

4-amino-5-chloro-2-methoxybenzonitrile

4-amino-5-chloro-2-methoxybenzamide

4-amino-5-chloro-2-methoxybenzoic acid

Downstream raw materials:

4-(2-chloro-4-cyano-5-methoxy-phenyl)-2-methylsulfanyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

4-(2-chloro-4-cyano-5-methoxy-phenyl)-2-methanesulfonyl-7-(2-trimethylsilanyl-ethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Refernces

• 1、 -. "PYRROLOPYRIMIDINE DERIVATIVES HAVING HSP90 INHIBITORY ACTIVITY". Page/Page column 47. . Retrieved 2009/04/25.