Technology Process of 6-CHLORO-3,4-DIHYROGEN-4-METHYL-3-OXO-2H-1,4-BENZOXAZOLE-8-ACYLCHLORIDE
There total 7 articles about 6-CHLORO-3,4-DIHYROGEN-4-METHYL-3-OXO-2H-1,4-BENZOXAZOLE-8-ACYLCHLORIDE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
thionyl chloride; N,N-dimethyl-formamide;
In
1,2-dichloro-ethane;
at 60 ℃;
for 2h;
DOI:10.1248/cpb.40.624
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 86 percent / HNO3, conc. H2SO4 / 1 h / 0 - 5 °C
2: 79 percent / 0.78N aq. NH4Cl, Fe / toluene / 1 h / 85 - 90 °C
3: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C
4: K2CO3 / dimethylformamide / 2 h / 70 °C
5: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h
6: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating
7: SOCl2, DMF / 1,2-dichloro-ethane / 2 h / 60 °C
With
sodium hydroxide; thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; N,N-dimethyl-formamide;
In
ethanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.624
- Guidance literature:
-
Multi-step reaction with 5 steps
1: aq. NaHCO3 / CHCl3 / 2 h / 0 - 10 °C
2: K2CO3 / dimethylformamide / 2 h / 70 °C
3: 82.2 percent / K2CO3 / dimethylformamide / a) RT, 3 h, b) 40-45 deg C, 1 h
4: 81.5 percent / 5percent NaOH / ethanol / 3 h / Heating
5: SOCl2, DMF / 1,2-dichloro-ethane / 2 h / 60 °C
With
sodium hydroxide; thionyl chloride; sodium hydrogencarbonate; potassium carbonate; N,N-dimethyl-formamide;
In
ethanol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.624
