Technology Process of (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenol
There total 10 articles about (R)-(+)-5-benzyloxy-2,4-dimethyl-(E)-2-pentenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 20 ℃;
for 0.333333h;
Inert atmosphere;
DOI:10.1021/acs.orglett.5b03422
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at 25 ℃;
for 3h;
DOI:10.1021/ja00353a027
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) dichloromethane, -60 deg C, 30 min, 2.) -25 deg C, 15 min
2: 1.) butyllithium,diisopropylamine, 2.) oxalic acid dihydrate, 3.) water / 1.) THF, -78 deg C, 1.25 h, 25 deg C, 2 h, 2.) reflux, 1 h, 3.) reflux, 1.5 h
3: 95 percent / sodium borohydride / ethanol / 3 h / 25 °C
With
sodium tetrahydroborate; n-butyllithium; oxalyl dichloride; water; oxalic acid; dimethyl sulfoxide; triethylamine; diisopropylamine;
In
ethanol;
DOI:10.1021/ja00353a027
