(S)-ketoprofen chloride

Base Information

• Chemical Name: (S)-ketoprofen chloride
• CAS No.: 109718-56-1
• Molecular Formula: C₁₆H₁₃ClO₂
• Molecular Weight: 272.731
• Mol file: 109718-56-1.mol

Synonyms:(S)-ketoprofen chloride

Chemical Property of (S)-ketoprofen chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-ketoprofen chloride

There total 9 articles about (S)-ketoprofen chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ketoprofen (22071-15-4,22161-86-0) → ketoprofen chloride (59512-44-6,71381-92-5,109718-56-1)

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane; at 40 ℃; for 0.5h;

DOI:10.1039/b718068c

Reference yield:

S-ketoprofen (22161-81-5,22161-86-0) → (S)-ketoprofen chloride (109718-56-1)

Guidance literature:

With thionyl chloride; In dichloromethane;

DOI:10.1021/ol061854c

Reference yield:

thionyl chloride (7719-09-7) + ketoprofen (22071-15-4,22161-86-0) → ketoprofen chloride (59512-44-6,71381-92-5,109718-56-1)

Guidance literature:

In tetrahydrofuran; at 67 ℃; for 6h;

upstream raw materials:

ketoprofen

thionyl chloride

α-(3-benzylphenyl)-propionic acid

aniline

Downstream raw materials:

2-(3-benzoyl-phenyl)-N-(4,5-dihydro-thiazol-2-yl)-propionamide

2-cyclohexylmethyl-1-[α-(3-benzoylphenyl)propionyl]piperidine

2-(3-Benzoyl-phenyl)-propionic acid 2-acetoxy-1-acetoxymethyl-ethyl ester

(R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester

Refernces

• 1、 Ravera, Mauro,Zanellato, Ilaria,Gabano, Elisabetta,Perin, Elena,Rangone, Beatrice,Coppola, Marco,Osella, Domenico. "Antiproliferative activity of Pt(IV) conjugates containing the non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen and Naproxen". . . Retrieved 2019.
• 2、 Borhade, Namdev,Pathan, Asif Rahimkhan,Halder, Somnath,Karwa, Manoj,Dhiman, Mini,Pamidiboina, Venu,Gund, Machhindra,Deshattiwar, Jagannath Janardhan,Mali, Sunil Vasantrao,Deshmukh, Nitin Janardanrao,Senthilkumar, Subrayan Palanisamy,Gaikwad, Parikshit,Tipparam, Santhosh Goud,Mudgal, Jayesh,Dutta, Milan Chandra,Burhan, Aslam Usmangani,Thakre, Gajanan,Sharma, Ankur,Deshpande, Shubhada,Desai, Dattatraya Chandrakant,Dubash, Nauzer Pervez,Jain, Arun Kumar,Sharma, Somesh,Nemmani, Kumar Venkata Subrahmanya,Satyam, Apparao. "NO-NSAIDs. Part 3: Nitric oxide-releasing prodrugs of non-steroidal anti-inflammatory drugs". . p. 465 - 481. Retrieved 2012.
• 3、 Venteicher, Brooklynn,Merklin, Kasey,Ngo, Huy X.,Chien, Huan-Chieh,Hutchinson, Keino,Campbell, Jerome,Way, Hannah,Griffith, Joseph,Alvarado, Cesar,Chandra, Surabhi,Hill, Evan,Schlessinger, Avner,Thomas, Allen A.. "The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake". . p. 869 - 880. Retrieved 2020/12/15.
• 4、 -. "New group of dexketoprofen trometamol new impurity and preparation method thereof". Paragraph 0005. . Retrieved 2021/10/02.