(+)-(R)-Benproperinium dihydrogen phosphate

Base Information

• Chemical Name: (+)-(R)-Benproperinium dihydrogen phosphate
• CAS No.: 124678-31-5
• Molecular Formula: C21H30NO5P
• Molecular Weight: 407.447
• Mol file: 124678-31-5.mol

Synonyms:(+)-(R)-Benproperinium dihydrogen phosphate;Piperidine, 1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]-, (R)-, phosphate (1:1)

Chemical Property of (+)-(R)-Benproperinium dihydrogen phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(R)-Benproperinium dihydrogen phosphate

There total 5 articles about (+)-(R)-Benproperinium dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine (2156-27-6,124700-66-9) → Benproperine phosphate (124678-31-5)

Guidance literature:

With phosphoric acid; In toluene; pH=4 - 5; Green chemistry;

Reference yield:

phenol (108-95-2,27073-41-2) → Benproperine phosphate (124678-31-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,1,3,3-tetrakis((trifluoromethyl)sulfonyl)prop-1-ene / Green chemistry

2: sodium hydroxide / water / 4 h / 65 - 100 °C / Green chemistry

3: Dichloromethylsilane; iron(III) chloride / 1,2-dimethoxyethane / 4 h / 84 °C / Reflux; Green chemistry

4: 72 h / 140 °C / Inert atmosphere; Green chemistry

5: phosphoric acid / toluene / pH 4 - 5 / Green chemistry

With Dichloromethylsilane; iron(III) chloride; phosphoric acid; 1,1,3,3-tetrakis((trifluoromethyl)sulfonyl)prop-1-ene; sodium hydroxide; In 1,2-dimethoxyethane; water; toluene;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → Benproperine phosphate (124678-31-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1,1,3,3-tetrakis((trifluoromethyl)sulfonyl)prop-1-ene / Green chemistry

2: sodium hydroxide / water / 4 h / 65 - 100 °C / Green chemistry

3: Dichloromethylsilane; iron(III) chloride / 1,2-dimethoxyethane / 4 h / 84 °C / Reflux; Green chemistry

4: 72 h / 140 °C / Inert atmosphere; Green chemistry

5: phosphoric acid / toluene / pH 4 - 5 / Green chemistry

With Dichloromethylsilane; iron(III) chloride; phosphoric acid; 1,1,3,3-tetrakis((trifluoromethyl)sulfonyl)prop-1-ene; sodium hydroxide; In 1,2-dimethoxyethane; water; toluene;

upstream raw materials:

1-[1-methyl-2-[2-(phenylmethyl)phenoxy]ethyl]piperidine

phenol

benzyl alcohol

o-Benzylphenol

Refernces