N-(DIETHYLCARBAMOYL)-N-METHOXYFORMAMIDE

Base Information

• Chemical Name: N-(DIETHYLCARBAMOYL)-N-METHOXYFORMAMIDE
• CAS No.: 146039-03-4
• Molecular Formula: C7H14 N2 O3
• Molecular Weight: 174.2
• Hs Code.: 2924210090
• Mol file: 146039-03-4.mol

Synonyms:N-(Diethylcarbamoyl)-N-methoxyformamide;N-(N,N-Diethylcarbamoyl)-N-methoxyformamide

Chemical Property of N-(DIETHYLCARBAMOYL)-N-METHOXYFORMAMIDE

Chemical Property:

• Vapor Pressure: 0.152mmHg at 25°C
• Refractive Index: 1.462
• Boiling Point: 96 °C / 3mmHg
• Flash Point: 83.8°C
• PSA: 49.85000
• Density: 1.09
• LogP: 1.10390

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(Diethylcarbamoyl)-N-methoxyformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(DIETHYLCARBAMOYL)-N-METHOXYFORMAMIDE

There total 2 articles about N-(DIETHYLCARBAMOYL)-N-METHOXYFORMAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethylcarbamyl chloride (88-10-8) → N-(Diethylcarbamoyl)-N-methoxyformamide (146039-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Et₃N / CHCl₃ / 3 h / Heating

2: 1) AcCl, 2) 4-dimethylaminopyridine / 1) Et₂O, 20 min, 2) CH₂Cl₂, 0 deg C, 2 h

With dmap; triethylamine; acetyl chloride; In chloroform;

DOI:10.1055/s-1992-26298

Reference yield:

sodium formate (141-53-7) + 1,1-Diethyl-3-methoxyurea (89582-39-8) → N-(Diethylcarbamoyl)-N-methoxyformamide (146039-03-4)

Guidance literature:

With dmap; acetyl chloride; Yield given. Multistep reaction; 1) Et₂O, 20 min, 2) CH₂Cl₂, 0 deg C, 2 h;

DOI:10.1055/s-1992-26298

Reference yield: 96.0%

N-(Diethylcarbamoyl)-N-methoxyformamide (146039-03-4) + aniline (62-53-3) → Formanilid (103-70-8)

Guidance literature:

at 60 ℃; for 10.5h; other primary amines and amino acids;

DOI:10.1055/s-1992-26298

upstream raw materials:

sodium formate

1,1-Diethyl-3-methoxyurea

N,N-diethylcarbamyl chloride

Downstream raw materials:

N^ε-formyl-(2S)-lysine

N-formyl-phenylalanine

(S)-tert-butyl-2-formamido-3-phenylpropanoate

N-[(4-aminophenyl)methyl]formamide

Refernces