(4-Methylpyridin-2-yl)methanamine

Base Information

• Chemical Name: (4-Methylpyridin-2-yl)methanamine
• CAS No.: 129768-95-2
• Molecular Formula: C7H10 N2
• Molecular Weight: 122.17
• Hs Code.: 2933399090
• European Community (EC) Number: 835-058-3
• DSSTox Substance ID: DTXSID00569006
• Nikkaji Number: J3.376.421I
• Mol file: 129768-95-2.mol

Synonyms:(4-methylpyridin-2-yl)methanamine;129768-95-2;(4-Methylpyridin-2-yl)methylamine;2-(Aminomethyl)-4-methylpyridine;2-Pyridinemethanamine, 4-methyl-;2-Aminomethyl-4-methylpyridine;MFCD06213857;4-Methyl-2-aminomethylpyridine;4-METHYL-2-PYRIDINEMETHANAMINE;SCHEMBL318010;2-aminomethyl-4-methyl pyridine;(4-Methyl-2-pyridyl)methanamine;DTXSID00569006;QVDFBCYBLHPIOI-UHFFFAOYSA-N;(4-methyl-2-pyridyl) methanamine;[(4-methylpyridin-2-yl)methyl]amine;1-(4-Methylpyridin-2-yl)methanamine;AKOS006343724;AB23452;PS-5699;AM803142;SY032971;A2702;CS-0084608;EN300-97212;(4-methylpyridin-2-yl)methanamine, AldrichCPR;W-205318;F2147-2304

Chemical Property of (4-Methylpyridin-2-yl)methanamine

Chemical Property:

• Boiling Point: 217.4±25.0 °C(Predicted)
• PKA: 8.75±0.39(Predicted)
• PSA: 38.91000
• Density: 1.027±0.06 g/cm3(Predicted)
• LogP: 1.54900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.084398327
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-Methylpyridin-2-Yl)methylamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC=C1)CN

Technology Process of (4-Methylpyridin-2-yl)methanamine

There total 3 articles about (4-Methylpyridin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Cyano-4-methylpyridin (1620-76-4) → 1-(4-methylpyridin-2-yl)methanamine (129768-95-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

DOI:10.1021/jacs.5b09463

Reference yield: 19.0%

→ 1-(4-methylpyridin-2-yl)methanamine (129768-95-2)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; under 3800.26 Torr; Autoclave;

With potassium carbonate; In water;

Reference yield:

2-Cyano-4-methylpyridin (1620-76-4) + of ammonia → 1-(4-methylpyridin-2-yl)methanamine (129768-95-2)

Guidance literature:

Ni-Raney; In methanol;

upstream raw materials:

2-Cyano-4-methylpyridin

Refernces

• 1、 -. "PRODUCTION METHOD OF OPTICALLY ACTIVE SECONDARY ALCOHOL". Paragraph 0127; 0129. . Retrieved 2016/11/14.
• 2、 -. "Heterocyclic piperidinyl compounds having analgesic effect". . . Retrieved 2008/06/13.