2-Methyl-4-(piperazin-1-YL)pyrimidine

Base Information

• Chemical Name: 2-Methyl-4-(piperazin-1-YL)pyrimidine
• CAS No.: 131816-67-6
• Molecular Formula: C9H14 N4
• Molecular Weight: 178.237
• Hs Code.: 2933990090
• European Community (EC) Number: 848-558-1
• DSSTox Substance ID: DTXSID40564555
• Wikidata: Q82449291
• Mol file: 131816-67-6.mol

Synonyms:131816-67-6;2-METHYL-4-(PIPERAZIN-1-YL)PYRIMIDINE;2-METHYL-4-PIPERAZIN-1-YLPYRIMIDINE;2-Methyl-4-(1-piperazinyl)pyrimidine;Pyrimidine, 2-methyl-4-(1-piperazinyl)- (9CI);2-Methyl-4-piperazino-pyrimidine;SCHEMBL6976678;DTXSID40564555;WYEQVNKICBCRPY-UHFFFAOYSA-N;AKOS012077877;AB59358;AT18345;CS-0046007;EN300-135528;PYRIMIDINE, 2-METHYL-4-(1-PIPERAZINYL)-;F8889-0597

Chemical Property of 2-Methyl-4-(piperazin-1-YL)pyrimidine

Chemical Property:

• PSA: 41.05000
• LogP: 0.58840
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 178.121846464
• Heavy Atom Count: 13
• Complexity: 156

Purity/Quality:

98%min ^*data from raw suppliers

2-methyl-4-piperazin-1-ylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC=CC(=N1)N2CCNCC2

Technology Process of 2-Methyl-4-(piperazin-1-YL)pyrimidine

There total 1 articles about 2-Methyl-4-(piperazin-1-YL)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperazine (110-85-0) + 4-chloro-2-methylpyrimidine (4994-86-9) → 1-(2-methylpyrimidin-4-yl)piperazine (131816-67-6)

Guidance literature:

In tetrahydrofuran;

Reference yield:

1-(2-methylpyrimidin-4-yl)piperazine (131816-67-6) + 1-(4-Bromophenylsulphonyl)-4methyl-piperidine-4-carboxylic acid → 1-(bromophenylsulphonyl)-4-[1-(2-methylpyrimidin-4-yl)piperazin-4-ylcarbonyl]-4-methyl-piperidine

Guidance literature:

With thionyl chloride; triethylamine; In dichloromethane;

Reference yield:

1-(2-methylpyrimidin-4-yl)piperazine (131816-67-6) + benzoyl chloride (98-88-4) → 2-methyl-4-(4-benzoyl-piperazino)-pyrimidine (131816-56-3)

Guidance literature:

With potassium carbonate; In acetone;

upstream raw materials:

piperazine

4-chloro-2-methylpyrimidine

Downstream raw materials:

2-methyl-4-(4-benzoyl-piperazino)-pyrimidine

Refernces