N,2'-Dimethylformanilide

Base Information

• Chemical Name: N,2'-Dimethylformanilide
• CAS No.: 131840-54-5
• Molecular Formula: C9H11NO
• Molecular Weight: 149.192
• Hs Code.: 2924297099
• DSSTox Substance ID: DTXSID50577737
• Nikkaji Number: J518.836I
• Wikidata: Q82467822
• Mol file: 131840-54-5.mol

Synonyms:N,2'-Dimethylformanilide;131840-54-5;N-Methyl-N-(2-methylphenyl)formamide;Formamide, N-methyl-N-(2-methylphenyl)-;N-Methyl-N-(o-tolyl)formamide;N,2 -DIMETHYLFORMANILIDE;SCHEMBL2093826;WWWSJNJIEHCOSE-UHFFFAOYSA-;DTXSID50577737;N,2/'-DIMETHYLFORMANILIDE;WWWSJNJIEHCOSE-UHFFFAOYSA-N;MFCD09038514;AKOS013154139;AS-64045;CS-0315195;D3368;T70208;InChI=1/C9H11NO/c1-8-5-3-4-6-9(8)10(2)7-11/h3-7H,1-2H3

Chemical Property of N,2'-Dimethylformanilide

Chemical Property:

• Refractive Index: 1.5370-1.5410
• Boiling Point: 206 °C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

98% ^*data from raw suppliers

N,2''-Dimethylformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1N(C)C=O

Technology Process of N,2'-Dimethylformanilide

There total 8 articles about N,2'-Dimethylformanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2'-methylformanilide (94-69-9) + dimethyl sulfate (77-78-1) → N'-methyl-N-(2-methylphenyl)formanilide (131840-54-5) + N,2-dimethylaniline (611-21-2)

Guidance literature:

With hexamethylenetetramine hydrobromide; potassium carbonate; In benzene; at 8 - 10 ℃; for 0.75h;

DOI:10.1080/00397919208021146

Reference yield: 90.0%

carbon dioxide (124-38-9,18923-20-1) + N,2-dimethylaniline (611-21-2) → N'-methyl-N-(2-methylphenyl)formanilide (131840-54-5)

Guidance literature:

With dimanganese decacarbonyl; phenylsilane; C₂₉H₃₃N₂P; In acetonitrile; at 20 ℃; under 750.075 Torr;

DOI:10.1002/cssc.201900152

Reference yield: 84.0%

carbon dioxide (124-38-9,18923-20-1) + N-methylaniline (100-61-8) → N'-methyl-N-(2-methylphenyl)formanilide (131840-54-5)

Guidance literature:

With dimethylamine borane; In water; at 100 ℃; for 24h; under 18751.9 Torr; Heating; Green chemistry;

DOI:10.1007/s10562-018-2608-9

upstream raw materials:

2'-methylformanilide

methyl iodide

dimethyl sulfate

carbon dioxide

Downstream raw materials:

N,N-dimethyl-o-toluidine

N,2-dimethylaniline

Refernces

• 1、 Li, Hu,Li, Zhengyi,Wu, Hongguo,Yang, Song,Yu, Zhaozhuo,Zhang, Lilong,Zhu, Kaixun. "A substituent- And temperature-controllable NHC-derived zwitterionic catalyst enables CO2upgrading for high-efficiency construction of formamides and benzimidazoles". supporting information. p. 5759 - 5765. Retrieved 2021/08/23.
• 2、 Du, Chen-Xia,Huang, Zijun,Jiang, Xiaolin,Li, Yuehui,Makha, Mohamed,Wang, Fang,Zhao, Dongmei. "Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide". supporting information. p. 5317 - 5324. Retrieved 2020/09/17.