3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE
• CAS No.: 637031-93-7
• Molecular Formula: C4H8ClF2N
• Molecular Weight: 143.564
• Hs Code.: 2921300090
• Mol file: 637031-93-7.mol

Synonyms:Cyclobutanamine,3,3-difluoro-, hydrochloride (9CI);3,3-Difluorocyclobutanamine hydrochloride;

Chemical Property of 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 75.54mmHg at 25°C
• Melting Point: 296 °C
• Refractive Index: 1.405
• Boiling Point: 83.394°C at 760 mmHg
• Flash Point: -11.021°C
• PSA: 26.02000
• Density: 1.175g/cm³
• LogP: 2.24510
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%, ^*data from raw suppliers

3,3-Difluorocyclobutanamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,3-Difluorocyclobutanamine hydrochloride is used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors. 3-Halo substituted cyclobutanamine used in the preparation of piperazinyl antiviral agents as well as kinase inhibitors.

Technology Process of 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE

There total 5 articles about 3,3-DIFLUOROCYCLOBUTANAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3,3-difluorocyclobutyl-1-amine (791061-00-2) → 3,3-difluorocyclobutylamine hydrochloride (637031-93-7)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 10 - 15 ℃; for 8h; Solvent;

Reference yield: 88.4%

3,3-difluorocyclobutane-1-carboxamide (86770-82-3) → 3,3-difluorocyclobutylamine hydrochloride (637031-93-7)

Guidance literature:

3,3-difluorocyclobutane-1-carboxamide; With sodium hypochlorite; sodium hydroxide; In tetrahydrofuran; at 0 - 40 ℃; for 7h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h; Reagent/catalyst;

Reference yield: 86.0%

tert-butyl (3,3-difluorocyclobutyl)carbamate (1029720-19-1) → 3,3-difluorocyclobutylamine hydrochloride (637031-93-7)

Guidance literature:

With hydrogenchloride; In water; at 110 ℃; for 2h;

DOI:10.1016/j.bmcl.2013.04.049

upstream raw materials:

3,3-difluorocyclobutanecarboxylic acid

benzyl (3,3-difluorocyclobutyl)carbamate

tert-butyl (3,3-difluorocyclobutyl)carbamate

3,3-difluorocyclobutane-1-carboxamide

Downstream raw materials:

N-(3,3-difluorocyclobutyl)formamide

Refernces

• 1、 Chandrachud, Preeti P.,Wojtas, Lukasz,Lopchuk, Justin M.. "Decarboxylative Amination: Diazirines as Single and Double Electrophilic Nitrogen Transfer Reagents". supporting information. p. 21743 - 21750. Retrieved 2021/01/11.
• 2、 Melnykov, Kostiantyn P.,Granat, Dmitriy S.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.. "Multigram Synthesis of C 4/C5 3,3-Difluorocyclobutyl-Substituted Building Blocks". . p. 4949 - 4957. Retrieved 2018/12/13.