S-(+)-Isoflurane

Base Information

• Chemical Name: S-(+)-Isoflurane
• CAS No.: 133098-05-2
• Molecular Formula: C3H2ClF5O
• Molecular Weight: 184.49
• Mol file: 133098-05-2.mol

Synonyms:(S)-Isoflurane;Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-, (2S)- (9CI);Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-, (S)-;S-(+)-Isoflurane

Chemical Property of S-(+)-Isoflurane

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-(+)-Isoflurane

There total 10 articles about S-(+)-Isoflurane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,1-Dichloro-2,2,2-trifluoroethyl difluoromethyl ether (32778-07-7) → isoflurane (26675-46-7,133098-05-2)

Guidance literature:

In water; acetone; for 20h; Irradiation;

DOI:10.1016/S0022-1139(96)03504-X

Reference yield: 88.3%

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) + difluoromethyl alcohol (1426-06-8) → isoflurane (26675-46-7,133098-05-2)

Guidance literature:

at 30 - 35 ℃; for 3h; Temperature; Autoclave; Inert atmosphere;

Reference yield: 67.0%

1-chloro-2,2,2-trifluoroethyl chlorofluoromethyl ether → isoflurane (26675-46-7,133098-05-2)

Guidance literature:

With diisopropylethylamine hydrofluoride; N-ethyl-N,N-diisopropylamine; for 21h; Heating;

DOI:10.1016/S0022-1139(01)00396-7

upstream raw materials:

1,1,1-trifluoro-2-difluoromethoxypropane

1-Chlor-2,2,2-trifluorethyl-dichlormethylether

1,1-Dichloro-2,2,2-trifluoroethyl difluoromethyl ether

1,1,1-trifluoro-2,2-dichloroethane

Refernces

• 1、 Kudzma,Huang,Lessor,Rozov,Afrin,Kallashi,McCutcheon,Ramig. "Diisopropylethylamine mono(hydrogen fluoride) for nucleophilic fluorination of sensitive substrates: Synthesis of sevoflurane". . p. 11 - 16. Retrieved 2001.
• 2、 Ramig, Keith,Quiroz, Fernando,Vernice, Gerald G.,Rozov, Leonid A.. "Selective free-radical dechlorination of 1,1-dichloro-2,2,2-trifluoroethyl difluoromethyl ether initiated thermally or by UV light: A practical and 'green' method for isoflurane synthesis". . p. 101 - 104. Retrieved 1996.
• 3、 -. "Preparation method of isoflurane". Paragraph 0021; 0034; 0036-0037; 0039-0040; 0042-0043; 0045. . Retrieved 2020/12/15.