(5-Cyanopyridin-3-yl)-methanol

Base Information

• Chemical Name: (5-Cyanopyridin-3-yl)-methanol
• CAS No.: 135124-71-9
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.137
• Hs Code.: 2933399090
• Mol file: 135124-71-9.mol

Synonyms:3-Pyridinecarbonitrile, 5-(hydroxymethyl)-(9CI);

Chemical Property of (5-Cyanopyridin-3-yl)-methanol

Chemical Property:

• Vapor Pressure: 0.00019mmHg at 25°C
• Refractive Index: 1.575
• Boiling Point: 315 °C at 760 mmHg
• PKA: 13.26±0.10(Predicted)
• Flash Point: 144.3 °C
• PSA: 56.91000
• Density: 1.25 g/cm³
• LogP: 0.44558
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-(Hydroxymethyl)Nicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-Cyanopyridin-3-yl)-methanol

There total 12 articles about (5-Cyanopyridin-3-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

5-((trityloxy)methyl)nicotinnitrile → 5-(hydroxymethyl)pyridine-3-carbonitrile (135124-71-9)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 60.7%

5-formylpyridine-3-carbonitrile (70416-53-4) → 5-(hydroxymethyl)pyridine-3-carbonitrile (135124-71-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 2.5h;

Reference yield: 57.6%

zinc(II) cyanide (557-21-1) + (5-bromopyridin-3-yl)methanol (37669-64-0) → 5-(hydroxymethyl)pyridine-3-carbonitrile (135124-71-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; Inert atmosphere;

upstream raw materials:

(5-bromopyridin-3-yl)methanol

copper(I) cyanide

3-Cyano-5-methoxycarbonylpyridine

5-bromo-3-pyridinecarboxylic acid

Downstream raw materials:

5-(chloromethyl)nicotinonitrile hydrochloride

5-formylpyridine-3-carbonitrile

5-(bromomethyl)pyridine-3-carbonitrile

5-aminomethyl-3-pyridinecarbonitrile

Refernces

• 1、 -. "Novel biphenyl derivative as well as preparation method and medical application thereof". Paragraph 0065; 0085; 0097-0099. . Retrieved 2021/07/21.
• 2、 -. "UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF". Paragraph 0072; 0073. . Retrieved 2019/11/14.