(R)-3-FLUORO-PYRROLIDINE

Base Information

• Chemical Name: (R)-3-FLUORO-PYRROLIDINE
• CAS No.: 136725-54-7
• Molecular Formula: C4H9FN
• Molecular Weight: 89.1126
• Hs Code.: 2933998090
• Mol file: 136725-54-7.mol

Synonyms:(R)-3-FLUORO-PYRROLIDINE;3(S)-fluoropyrrolidine

Chemical Property of (R)-3-FLUORO-PYRROLIDINE

Chemical Property:

• Vapor Pressure: 54.9mmHg at 25°C
• Refractive Index: 1.413
• Boiling Point: 91°C at 760 mmHg
• Flash Point: 8.8°C
• PSA: 15.27000
• Density: 0.99g/cm³
• LogP: 1.80910

Purity/Quality:

99.3% ^*data from raw suppliers

(3S)-3-Fluoropyrrolidine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-FLUORO-PYRROLIDINE

There total 1 articles about (R)-3-FLUORO-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-CBz-3-fluoropyrrolidine (136725-52-5) → (3S)-3-fluoropyrrolidine (136725-54-7,116574-74-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2003.12.040

Reference yield: 85.4%

methyl 4-((((4-nitrophenoxy)carbonyl)(6-(trifluoromethyl)pyridin-2-yl)amino)methyl)benzoate + (3S)-3-fluoropyrrolidine (136725-54-7,116574-74-4) → (S)-methyl 4-((3-fluoro-N-(6-(trifluoromethyl)pyridin-2-yl)pyrrolidine-1-carboxamido)methyl)benzoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield: 75.0%

methyl 4-((((4-nitrophenoxy)carbonyl)(3-(trifluoromethyl)phenyl)amino)methyl)benzoate + (3S)-3-fluoropyrrolidine (136725-54-7,116574-74-4) → (S)-methyl 4-((3-fluoro-N-(3-(trifluoromethyl)phenyl)pyrrolidine-1-carboxamido)methyl)benzoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

upstream raw materials:

(S)-N-CBz-3-fluoropyrrolidine

Downstream raw materials:

(2S,3S)-2-Azido-3-(4-bromo-phenyl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one

Refernces

• 1、 Caldwell, Charles G.,Chen, Ping,He, Jiafang,Parmee, Emma R.,Leiting, Barbara,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Eiermann, George J.,Petrov, Aleksandr,He, Huaibing,Lyons, Kathryn A.,Thornberry, Nancy A.,Weber, Ann E.. "Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors". . p. 1265 - 1268. Retrieved 2007/10/03.