1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE
• CAS No.: 138227-69-7
• Molecular Formula: C17H26N2O3
• Molecular Weight: 306.405
• Hs Code.: 2933399090
• Mol file: 138227-69-7.mol

Synonyms:1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE;4-(4-AMINO-2-METHYL-PHENOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-4-(4-amino-2-methylphenoxy)piperidine

Chemical Property of 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 439.396°C at 760 mmHg
• Flash Point: 219.539°C
• PSA: 64.79000
• Density: 1.123g/cm³
• LogP: 3.87460

Purity/Quality:

98%min ^*data from raw suppliers

1-N-Boc-4-(4-Amino-2-Methylphenoxy)Piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE

There total 4 articles about 1-N-BOC-4-(4-AMINO-2-METHYLPHENOXY)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine (138227-68-6) → 1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine (138227-69-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 4h;

DOI:10.1248/cpb.56.758

Reference yield:

1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine (138227-68-6) + ethyl acetate (141-78-6) → 1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine (138227-69-7)

Guidance literature:

palladium; In methanol; hexane;

Reference yield:

5-nitro-2-fluorotoluene (455-88-9) → 1-tert-butyloxycarbonyl-4-(4-amino-2-methylphenyloxy)piperidine (138227-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 10 - 15 °C

1.2: 107 g / dimethylformamide / 3 h / 20 °C

2.1: 68 g / H₂ / Pd(OH)2 / ethanol / 16 h / 20 °C / 2327.23 Torr

With hydrogen; sodium hydride; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2007.03.046

upstream raw materials:

1-tert-butyloxycarbonyl-4-(4-nitro-2methylphenyloxy)piperidine

5-nitro-2-fluorotoluene

t-butyl 4-hydroxy piperidine-1-carboxylate

ethyl acetate

Downstream raw materials:

4-[4-(6-fluoro-pyrido[3,4-d]pyrimidin-4-ylamino)-2-methyl-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester

ethyl N-[4-(1-t-butoxycarbonylpiperidin-4-yloxy)-3-methylphenyl]sulfamoylacetate

Refernces

• 1、 Lippa, Blaise,Kauffman, Goss S.,Arcari, Joel,Kwan, Tricia,Chen, Jinshan,Hungerford, William,Bhattacharya, Samit,Zhao, Xumiao,Williams, Courtney,Xiao, Jun,Pustilnik, Leslie,Su, Chunyan,Moyer, James D.,Ma, Ling,Campbell, Mary,Steyn, Stefanus. "The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer". . p. 3081 - 3086. Retrieved 2008/02/03.
• 2、 -. "BENZAMIDINE DERIVATIVE". Page 160. . Retrieved 2010/02/05.