3-(TRIFLUOROMETHOXY)BENZYLAMINE

Base Information

• Chemical Name: 3-(TRIFLUOROMETHOXY)BENZYLAMINE
• CAS No.: 93071-75-1
• Molecular Formula: C8H8 F3 N O
• Molecular Weight: 191.153
• Hs Code.: 29215900
• Mol file: 93071-75-1.mol

Synonyms:3-Trifluoromethoxybenzylamine;[3-(Trifluoromethoxy)phenyl]methanamine;[[3-(Trifluoromethoxy)phenyl]methyl]amine; [[3-[(Trifluoromethyl)oxy]phenyl]methyl]amine

Chemical Property of 3-(TRIFLUOROMETHOXY)BENZYLAMINE

Chemical Property:

• Vapor Pressure: 0.488mmHg at 25°C
• Refractive Index: 1.451-1.454
• Boiling Point: 192.5°Cat760mmHg
• PKA: 8.70±0.10(Predicted)
• Flash Point: 82.8°C
• PSA: 35.25000
• Density: 1.34g/cm³
• LogP: 2.74420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Air Sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Trifluoromethoxy)benzylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C,Xn
• Statements: 34-43-22
• Safety Statements: 45-36/37/39-26-36/37-23-20

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(TRIFLUOROMETHOXY)BENZYLAMINE

There total 2 articles about 3-(TRIFLUOROMETHOXY)BENZYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-cyano-3-trifluoromethoxybenzene (52771-22-9) → 1-[3-(trifluoromethoxy)phenyl]methanamine (93071-75-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

DOI:10.3390/ijms21228780

Reference yield:

→ 1-[3-(trifluoromethoxy)phenyl]methanamine (93071-75-1)

Guidance literature:

Reference yield: 100.0%

cyclohexanedione monoethylene ketal (4746-97-8) + 1-[3-(trifluoromethoxy)phenyl]methanamine (93071-75-1) → N-[3-(trifluoromethoxy)benzyl]-1,4-dioxaspiro[4.5]decan-8-amine (1031289-46-9)

Guidance literature:

cyclohexanedione monoethylene ketal; 1-[3-(trifluoromethoxy)phenyl]methanamine; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃;

With sodium hydroxide; In tetrahydrofuran; water;

upstream raw materials:

1-cyano-3-trifluoromethoxybenzene

Refernces

• 1、 -. "Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same". . . Retrieved 2008/06/13.