HC YELLOW NO. 15

Base Information

• Chemical Name: HC YELLOW NO. 15
• CAS No.: 138377-66-9
• Molecular Formula: C9H11N3O4
• Molecular Weight: 225.2
• Mol file: 138377-66-9.mol

Synonyms:HC YELLOW NO. 15

Chemical Property of HC YELLOW NO. 15

Chemical Property:

• PSA: 122.16000
• LogP: 1.57830

Purity/Quality:

99.0%min ^*data from raw suppliers

4-[(2-hydroxyethyl)amino]-3-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of HC YELLOW NO. 15

There total 3 articles about HC YELLOW NO. 15 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-fluoro-3-nitrobenzamide (349-02-0) + ethanolamine (141-43-5) → 4-(2'-hydroxyethyl)amino-3-nitrobenzamide (138377-66-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 90 ℃; for 5h;

DOI:10.1016/j.bmcl.2016.05.078

Reference yield:

CHCl3:MeOH + ethanolamine (141-43-5) + 4-chloro-3-nitrobenzamide (16588-06-0) → 4-(2'-hydroxyethyl)amino-3-nitrobenzamide (138377-66-9)

Guidance literature:

Reference yield:

3-nitro-4-fluorobenzoic acid (453-71-4) → 4-(2'-hydroxyethyl)amino-3-nitrobenzamide (138377-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-hydroxybenzotriazole ammonium salt / acetonitrile; N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 5 h / 90 °C

With N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1016/j.bmcl.2016.05.078

upstream raw materials:

ethanolamine

4-chloro-3-nitrobenzamide

3-nitro-4-fluorobenzoic acid

4-fluoro-3-nitrobenzamide

Refernces

• 1、 -. "Compositions containing nitroaniline dyes having a carbamide substituent group". . . Retrieved 2008/06/13.