methyl indoline-5-carboxylate

Base Information

• Chemical Name: methyl indoline-5-carboxylate
• CAS No.: 141452-01-9
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 2933990090
• Mol file: 141452-01-9.mol

Synonyms:Methyl2,3-dihydro-1H-indole-5-carboxylate;

Chemical Property of methyl indoline-5-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 67-69 °C
• Refractive Index: 1.555
• Boiling Point: 330.955 °C at 760 mmHg
• PKA: 2.65±0.20(Predicted)
• Flash Point: 153.956 °C
• PSA: 38.33000
• Density: 1.162 g/cm³
• LogP: 1.57920
• Storage Temp.: Refrigerated.
• Solubility.: DMSO (Sparingly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

Methylindoline-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl indoline-5-carboxylate

There total 6 articles about methyl indoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-methoxycarbonylindole (1011-65-0) → 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (141452-01-9)

Guidance literature:

With sodium cyanoborohydride; acetic acid; at 0 - 20 ℃; for 1.08333h;

Reference yield:

sulfuric acid (7664-93-9) + 5-methoxycarbonylindole (1011-65-0) → 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (141452-01-9)

Guidance literature:

With ammonia; palladium on charcoal; In methanol; water;

Reference yield:

methanol (67-56-1) + 2,3-dihydro-1H-indole-5-formic acid (15861-30-0) → 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester (141452-01-9)

Guidance literature:

With sulfuric acid; for 8h; Reflux;

upstream raw materials:

methyl 1-acetylindoline-5-carboxylate

5-methoxycarbonylindole

1-Acetyl-2,3-dihydro-1H-indole

1-acetylindoline-5-carboxylic acid

Downstream raw materials:

1-methanesulfonyl-2,3-dihydro-1H-indole-5-carboxylic acid

Refernces

• 1、 Lee, Hsueh-Yun,Wang, Li-Ting,Li, Yu-Hsuan,Pan, Shiow-Lin,Chen, Yi-Lin,Teng, Che-Ming,Liou, Jing-Ping. "Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases". . p. 8966 - 8976. Retrieved 2014.
• 2、 De, Pinaki Bhusan,Pradhan, Sourav,Banerjee, Sonbidya,Punniyamurthy, Tharmalingam. "Expedient cobalt(II)-catalyzed site-selective C7-arylation of indolines with arylboronic acids". . p. 2494 - 2497. Retrieved 2018.
• 3、 -. "PGDH INHIBITORS AND METHODS OF MAKING AND USING". Paragraph 0271; 0460-0461. . Retrieved 2021/07/31.
• 4、 Borghs, Jannik C.,Rueping, Magnus,Zubar, Viktoriia. "Hydrogenation or Dehydrogenation of N-Containing Heterocycles Catalyzed by a Single Manganese Complex". supporting information. . Retrieved 2020/05/19.