3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE

Base Information

• Chemical Name: 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE
• CAS No.: 145959-21-3
• Molecular Formula: C9H10 Cl N O2
• Molecular Weight: 199.637
• Hs Code.: 2924299090
• Mol file: 145959-21-3.mol

Synonyms:3-Chloro-N-methoxy-N-methylbenzamide;3-Chloro-N-methoxy-N-methylbenzylamide

Chemical Property of 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 335.885°C at 760 mmHg
• Flash Point: 156.938°C
• PSA: 29.54000
• Density: 1.224g/cm³
• LogP: 1.97340
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-N-methoxy-N-methylbenzamide 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-Chloro-N-methoxy-N-methylbenzamide is an intermediate in the synthesis of ketamine related compounds with potential anesthetic properties.

Technology Process of 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE

There total 11 articles about 3-CHLORO-N-METHOXY-N-METHYLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + m-Chlorobenzoyl chloride (618-46-2) → 3-chloro-N-methoxy-N-methylbenzamide (145959-21-3)

Guidance literature:

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; Inert atmosphere;

m-Chlorobenzoyl chloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2009.12.090

Reference yield: 92.0%

carbon monoxide (201230-82-2) + 3-iodochlorobenzene (625-99-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 3-chloro-N-methoxy-N-methylbenzamide (145959-21-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; sodium carbonate; In acetonitrile; at 80 ℃; for 8h; under 760.051 Torr; Autoclave; Inert atmosphere;

DOI:10.1039/c4ob00729h

Reference yield: 90.0%

m-chlorobenzyl alcohol (873-63-2) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 3-chloro-N-methoxy-N-methylbenzamide (145959-21-3)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) acetate monohydrate; calcium carbonate; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1055/s-0034-1379583

upstream raw materials:

m-Chlorobenzoyl chloride

N,0-dimethylhydroxylamine

N,O-dimethylhydroxylamine*hydrochloride

3-chlorophenylboronic acid

Downstream raw materials:

1-(3-chlorophenyl)-3-(dimethylamino)propan-1-one

3-(3-chlorobenzoyl)benzonitrile

(3Z,6Z)-3-((5-tert-butyl-1H-imidazol-4-yl)methylene)-6-(3-(3-chlorobenzoyl)benzylidene)piperazine-2,5-dione

3-(3-chlorobenzoyl)benzaldehyde

Refernces

• 1、 -. "ALK5 INHIBITORS". Paragraph 0479; 0975; 0976. . Retrieved 2020/07/07.
• 2、 Gim, Hyo Jin,Jung, Michael E.. "Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines". supporting information. p. 2548 - 2552. Retrieved 2019/06/08.