AC-LYS(FMOC)-OH

Base Information

• Chemical Name: AC-LYS(FMOC)-OH
• CAS No.: 148101-51-3
• Molecular Formula: C23H26 N2 O5
• Molecular Weight: 410.47
• Mol file: 148101-51-3.mol

Synonyms:AC-LYS(FMOC)-OH

Chemical Property of AC-LYS(FMOC)-OH

Chemical Property:

• Boiling Point: 709.4±60.0 °C(Predicted)
• PKA: 3.65±0.10(Predicted)
• PSA: 104.73000
• Density: 1.239±0.06 g/cm3(Predicted)
• LogP: 4.06650
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-Acetamido-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AC-LYS(FMOC)-OH

There total 3 articles about AC-LYS(FMOC)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.2%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + N2-acetyl-N6-L-lysine hydrochloride (152593-04-9) → N2-acetyl-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (148101-51-3)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; at 0 - 20 ℃; for 2h;

Reference yield:

N2-acetyl-N6-(tert-butyloxycarbonyl)-L-lysine (23500-04-1) → N2-acetyl-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (148101-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; acetone / 2 h / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; In water; ethyl acetate; acetone;

Reference yield:

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid (2418-95-3) → N2-acetyl-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (148101-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / tetrahydrofuran; water / 4 h / 0 - 20 °C

2: hydrogenchloride / ethyl acetate / 4 h / 0 - 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; acetone / 2 h / 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; water; ethyl acetate; acetone;

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

N²-acetyl-N⁶-L-lysine hydrochloride

N²-acetyl-N⁶-(tert-butyloxycarbonyl)-L-lysine

(S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid

Downstream raw materials:

N²-acetyl-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysyl-L-valyl-N⁵-carbamoyl-N-[4-({[(4-nitrophenoxy)carbonyl]oxy}methyl)phenyl]-L-ornithinamide

N²-acetyl-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysyl-L-valyl-N⁵-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide

Refernces