Technology Process of Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI)
There total 14 articles about Benzeneacetonitrile, 4-fluoro-alpha-hydroxy-, (alphaR)- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxynitrile lyase isozyme 5 from Prunus communis;
In
tert-butyl methyl ether;
at 25 ℃;
for 7h;
pH=5;
Enzymatic reaction;
DOI:10.1002/adsc.201601332
- Guidance literature:
-
4-fluorobenzaldehyde;
With
(S)-[1,1']-binaphthalenyl-2,2'-diol; lithium isopropoxide;
In
toluene;
for 0.166667h;
Cooling with acetone-dry ice;
Inert atmosphere;
trimethylsilyl cyanide;
In
toluene;
for 1.25h;
Cooling;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; toluene;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
With
(R)-oxynitrilase;
In
di-isopropyl ether;
at 20 ℃;
for 6h;
Enzymatic reaction;
DOI:10.21608/ejchem.2017.3262