2-Bromo-4,5-dimethoxytoluene

Base Information

• Chemical Name: 2-Bromo-4,5-dimethoxytoluene
• CAS No.: 52806-46-9
• Molecular Formula: C9H11BrO2
• Molecular Weight: 231.089
• Hs Code.: 2909309090
• Mol file: 52806-46-9.mol

Synonyms:2-Bromo-4,5-dimethoxytoluene

Chemical Property of 2-Bromo-4,5-dimethoxytoluene

Chemical Property:

• Vapor Pressure: 0.0204mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 259.9°C at 760 mmHg
• Flash Point: 106.4°C
• PSA: 18.46000
• Density: 1.36g/cm³
• LogP: 2.77470

Purity/Quality:

98% ^*data from raw suppliers

2-?Bromo-?4,?5-?dimethoxytoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-4,5-dimethoxytoluene is a building block that has been used as a reactant for the synthesis of xylopinine and catechol derivatives.

Technology Process of 2-Bromo-4,5-dimethoxytoluene

There total 8 articles about 2-Bromo-4,5-dimethoxytoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,2-dimethoxy-4-methylbenzene (494-99-5) → 1-bromo-4,5-dimethoxy-2-methylbenzene (52806-46-9)

Guidance literature:

With hydrogen bromide; In dimethyl sulfoxide; ethyl acetate; at 60 ℃; for 16h;

DOI:10.1002/anie.201801130

Reference yield: 83.0%

→ 1-bromo-4,5-dimethoxy-2-methylbenzene (52806-46-9)

Guidance literature:

Reference yield: 75.0%

1,2-dimethoxy-4-methylbenzene (494-99-5) → 1-bromo-4,5-dimethoxy-2-methylbenzene (52806-46-9) + 3,4-dimethoxy-benzaldehyde (120-14-9)

Guidance literature:

With hydrogen bromide; oxygen; In water; acetonitrile; at 20 ℃; for 10h; Irradiation;

DOI:10.1021/acscatal.5b02490

upstream raw materials:

1,2-dimethoxy-4-methylbenzene

5-bromo-2-methoxy-4-methylphenol

dimethyl sulfate

2-Methoxy-4-methylphenol

Downstream raw materials:

1,2-dimethoxy-4-methyl-5-nitrobenzene

2-bromo-4,5-dimethoxybenzoic acid

4-bromo-5-methylbenzene-1,2-diol

4-(4-Chlor-3-methyl-phenoxy)-5-methyl-veratrol

Refernces

• 1、 Sharma, Namita,Lee, Yong-Min,Li, Xiao-Xi,Nam, Wonwoo,Fukuzumi, Shunichi. "Regioselective Oxybromination of Benzene and Its Derivatives by Bromide Anion with a Mononuclear Nonheme Mn(IV)-Oxo Complex". supporting information. p. 14299 - 14303. Retrieved 2019/11/03.
• 2、 Li, Run,Wang, Zi Jun,Wang, Lei,Ma, Beatriz Chiyin,Ghasimi, Saman,Lu, Hao,Landfester, Katharina,Zhang, Kai. A. I.. "Photocatalytic Selective Bromination of Electron-Rich Aromatic Compounds Using Microporous Organic Polymers with Visible Light". . p. 1113 - 1121. Retrieved 2016/02/18.